President Donald Trump's pick to lead the Department of Labor, former Rep. Lori Chavez-DeRemer, R-Ore., has left Republicans in the Senate with some questions over her pro-union stances, but at the same time, she has generated some interest from pro-labor Democrats. 

In particular, the moderate Republican will need to explain to Republicans her support for the Protecting the Right to Organize Act (PRO Act), a controversial piece of legislation that was proposed a few years ago. 

Senate Majority Leader John Thune, R-S.D., told reporters that "support for the PRO Act is not something that most Republicans have tolerated in the past, but I think she's attempted to address that, and my hope is that she can further clarify her position on some of those issues when she goes through the hearing process."

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The Protecting the Right to Organize Act was championed by Democrats and the International Brotherhood of Teamsters upon introduction. But others, such as most Republicans and the U.S. Chamber of Commerce, opposed it. 

The legislation would effectively kill state-level laws that prohibit employers and unions from requiring workers to pay union dues as a condition of their employment. 

Chavez-DeRemer will have her hearing in front of the Senate Committee on Health, Education, Labor and Pensions (HELP) on Wednesday. 

One committee member she'll have to answer to is Sen. Rand Paul, R-Ky., who has already said he doesn't plan to support her. 

"Her support for the Pro Act, which would not only oppose national right to work, but it would preempt state law on right to work. I think it's not a good thing, and it'd be sort of hard for me since it's a big issue for me to support her. So I won't support her," the senator previously told reporters. 

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This puts Chavez-DeRemer in a difficult position, as she will need to rely on Democrats to help her advance out of the HELP committee favorably if Paul follows through on his commitment to voting against her. 

Sen. Markwayne Mullin, R-Okla., who is far from the most pro-union Republican in the upper chamber, is full speed ahead in favor of Trump's pick as Chavez-DeRemer gears up for her hearing and eventual committee vote. 

In a phone interview with Fox News Digital, he explained that he and Teamsters President Sean O'Brien were involved in Trump's selection of her for the key Cabinet role. Mullin further detailed the significance of union members in Trump's winning 2024 election coalition. 

He claimed Democrats have "come to us and actually said this is actually a really good pick" because it puts them in a difficult position and is hard to vote against with her support among labor unions. 

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The senator didn't give away any names of Democrats that might see her appeal, however. 

Paul previously predicted he wouldn't be the only one unwilling to back her in the Republican conference.

"I think she'll lose 15 Republicans and she'll get 25 Democrats. She's very pro-labor, she might get all the Democrats. Who knows? So, we'll see," he said. 

If his vote leaves her nomination tied at the committee level, it could still be reported and scheduled for a floor vote, but without a favorable recommendation. In this case, she would need to amass 60 votes in the full Senate to move on to confirmation. 

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With her appeal among labor groups, Chavez-DeRemer may manage to put together a 60-plus bipartisan coalition to be confirmed. 

While Paul predicted more than a dozen GOP defectors, Mullin said the real number is likely much smaller.

"I haven't heard from any other Republicans that are a ‘no.’ Rand is the only one," he said. 

"I don't think his numbers are accurate, even close," the Oklahoma Republican added. 

A representative for Chavez-DeRemer did not provide comment to Fox News Digital.

Sen. Rand Paul, R-Ky., is continuing his efforts to investigate the origins of the COVID-19 pandemic, and he wants answers from Dr. Anthony Fauci.   

In his new position as chairman of the Senate's Homeland Security committee, Paul issued subpoenas to 14 agencies from the outgoing Biden administration aimed at building on past congressional investigations into the COVID-19 virus and risky taxpayer-funded gain-of-function research. It is unclear who exactly from each agency will ultimately be deposed, but a Fauci deposition is possible. 

"In the wake of Anthony Fauci’s preemptive pardon, there are still questions to be answered," Paul said in a statement after announcing the issuance of his subpoenas. "Subpoenas were sent from the Committee to NIH [National Institutes of Health] and 13 other agencies regarding their involvement in risky gain-of-function research. The goal of the investigation will be to critique the process that allowed this dangerous research, that may have led to the pandemic, to occur in a foreign country under unsafe protocols and to ensure that there is sufficient oversight and review going forward, making sure a mistake of this magnitude never happens again."

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While former President Joe Biden preemptively pardoned Fauci to protect him from political retribution under the new Trump administration, legal experts have questioned the validity of such a pardon. Missouri Attorney General Andrew Baily suggested to Fox News that since Biden's own Justice Department indicated he lacked the mental faculties to be held criminally liable for improper handling of classified documents, it could be argued he also lacked the mens rea to issue pardons to people like Fauci. Additionally, the pardon Fauci received only covers his actions from January 2014 to the date of his pardon. As a result, a refusal to comply with a congressional subpoena could also potentially result in criminal charges.

Paul's investigation will build on a previous bipartisan probe launched by the Senate's Homeland Security committee last year looking into the national security threats posed by "high-risk biological research and technology in the U.S. and abroad." 

A second investigation being launched by Sen. Ron Johnson, R-Wis., the chairman of the Permanent Select Subcommittee on Investigations, will similarly probe concerns in the new Congress surrounding the COVID-19 pandemic and will include a review of email communications from Fauci.  

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Since the pandemic began, Paul has sent dozens of requests for information related to the origins of the COVID-19 virus and gain-of-function research. Last year, his efforts revealed documents that he said show that government officials from at least 15 federal agencies knew in 2018 that China's Wuhan Institute of Virology (WIV) was working on creating a coronavirus similar to COVID-19.

The WIV has been a centerpiece in the debate over the origins of COVID-19, as it was eventually discovered that American scientist Peter Daszak's EcoHealth Alliance was using taxpayer dollars to conduct risky research on the novel bat virus out of the WIV prior to the COVID-19 outbreak. Earlier this month, the Department of Health and Human Services barred Daszak and EcoHealth Alliance from receiving federal funding for five years. 

Meanwhile, Fauci, the director of the National Institute of Allergy and Infectious Diseases (NIAID), told Congress in May 2021 that the NIH "has not ever and does not now fund gain-of-function research in the Wuhan Institute of Virology."

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The Trump administration is reportedly preparing an executive order to halt all U.S. funding going towards gain-of-function research. 

Federal officials remain split on where the COVID-19 virus originated from. Three agencies — the Department of Energy, the FBI and the CIA — have determined that the most likely origin narrative is the lab leak theory, but others in the intelligence community and throughout the federal government say they can either not conclude that a lab leak was the most likely scenario, or they say that a natural origin scenario is most likely. A declassified intelligence report from 2021, published by the Office of the Director of National Intelligence, posited that if a lab leak did turn out to be the catalyst of the COVID-19 pandemic, it was likely the result of an accident.

Representatives for Paul declined to comment for this report, while Fauci did not respond to a request for comment. 

Sen. Rand Paul, R-Ky., on Sunday said he "couldn’t be happier" with President-elect Trump’s Cabinet nominees, saying he will work to push them through as quickly as possible.

When Paul was asked during an appearance on "Sunday Morning Futures" whether he would support all of Trump’s picks for his inner circle, the senator responded, "I couldn't have picked better."

"The vast majority I will support on day one," the senator said. "We’ll try to get Kristi Noem through Department of Homeland Security, Russ Vought for [Office of Management and Budget]. … I think in the first week you'll have half a dozen of them approved in the first week."

Paul said that he will control one committee in charge of confirming the nominees, adding, "I pledge to get them through as quickly as possible."

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Paul has said that he will chair the Senate Homeland Security and Governmental Affairs Committee with the start of the new Congress in January. 

Trump has handpicked an array of establishment and unconventional officials for the 15 top posts in his Cabinet, including Health and Human Services pick Robert F. Kennedy Jr., FBI Director selection Kash Patel and Sen. Marco Rubio as the nominee for Secretary of State.

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Some of Trump’s picks proved controversial, such as Patel, Defense Secretary pick Pete Hegseth and Director of National Intelligence nominee Tulsi Gabbard.

In late November, Fox News Digital learned that nearly a dozen of Trump’s Cabinet nominees and other appointees tapped for the incoming administration were targeted with "violent, unAmerican threats to their lives and those who live with them."