Science in Space: February 2025

February was first proclaimed as American Heart Month in 1964. Since then, its 28 (or 29) days have served as an opportunity to encourage people to focus on their cardiovascular health.

The International Space Station serves as a platform for a variety of ongoing research on human health, including how different body systems adapt to weightlessness. This research includes assessing cardiovascular health in astronauts during and after spaceflight and other studies using models of the cardiovascular system, such as tissue cultures. The goal of this work is to help promote heart health for humans in space and everyone on Earth. For this Heart Month, here is a look at some of this spaceflight research

Building a better heart model

Microgravity exposure is known to cause changes in cardiovascular function. Engineered Heart Tissues assessed these changes using 3D cultured cardiac tissues that model the behavior of actual heart tissues better than traditional cell cultures. When exposed to weightlessness, these “heart-on-a-chip” cells behaved in a manner similar to aging on Earth. This finding suggests that these engineered tissues can be used to investigate the effects of space radiation and long-duration spaceflight on cardiac function. Engineered tissues also could support development of measures to help protect crew members during a mission to Mars. Advanced 3D culture methodology may inform development of strategies to prevent and treat cardiac diseases on Earth as well.

Private astronaut heart health

For decades, human research in space has focused on professional and government-agency astronauts, but commercial spaceflight opportunities now allow more people to participate in microgravity research. Cardioprotection Ax-1 analyzed cardiovascular and general health in private astronauts on the 17-day Axiom-1 mission.

The study found that 14 health biomarkers related to cardiac, liver, and kidney health remained within normal ranges during the mission, suggesting that spaceflight did not significantly affect the health of the astronaut subjects. This study paves the way for monitoring and studying the effects of spaceflight on private astronauts and developing health management plans for commercial space providers.

Better measurements for better health

Vascular Echo, an investigation from CSA (Canadian Space Agency), examined blood vessels and the heart using a variety of tools, including ultrasound. A published study suggests that 3D imaging technology might better measure cardiac and vascular anatomy than the 2D system routinely used on the space station. The research team also developed a probe for the ultrasound device that better directs the beam, making it possible for someone who is not an expert in sonography to take precise measurements. This technology could help astronauts monitor heart health and treat cardiovascular issues on a long-duration mission to the Moon or Mars. The technology also could help patients on Earth who live in remote locations, where an ultrasound operator may not always be available.

Long-term heart health in space

As part of exploring ways to keep astronauts healthy on missions to the Moon and Mars, NASA is conducting a suite of space station studies called CIPHER that looks at the effects of spaceflight lasting up to a year. One CIPHER study, Vascular Calcium, examines whether calcium lost from bone during spaceflight might deposit in the arteries, increasing vessel stiffness and contributing to increased risk of future cardiovascular disease. Astronaut volunteers provide blood and urine samples and undergo ultrasound and high-resolution scans of their bones and arteries for this investigation. Another CIPHER study, Coronary Responses, uses advanced imaging tests to measure heart and artery response to spaceflight.

These studies will help scientists determine whether spaceflight accelerates narrowing and stiffening of the arteries, known as atherosclerosis, or increases the risk of atrial fibrillation, a rapid and irregular heartbeat seen in middle-aged adults. This work also could help identify potential biomarkers and early warning indicators of cardiovascular disease.

Melissa Gaskill

International Space Station Research Communications Team

Johnson Space Center

The latest edition of NASA’s Spinoff publication, which highlights the successful transfer of agency technology to the commercial sector, is now available online.

For nearly 25 years, NASA has supported crew working in low Earth orbit to learn about the space environment and perform research to advance deep space exploration. Astronauts aboard the International Space Station have learned a wealth of lessons and tried out a host of new technologies. This work leads to ongoing innovations benefiting people on Earth that are featured in NASA’s annual publication.  

“The work we do in space has resulted in navigational technologies, lifesaving medical advancements, and enhanced software systems that continue to benefit our lives on Earth,” said Clayton Turner, associate administrator, Space Technology Mission Directorate at NASA Headquarters in Washington. “Technologies developed today don’t just make life on our home planet easier – they pave the way to a sustained presence on the Moon and future missions to Mars.” 

The Spinoff 2025 publication features more than 40 commercial infusions of NASA technologies including: 

• A platform enabling commercial industry to perform science on the space station, including the growth of higher-quality human heart tissue, knee cartilage, and pharmaceutical crystals that can be grown on Earth to develop new medical treatments.  
• An electrostatic sprayer technology to water plants without the help of gravity and now used in sanitation, agriculture, and food safety.  
• “Antigravity” treadmills helping people with a variety of conditions run or walk for exercise, stemming from efforts to improve astronauts’ fitness in the weightlessness of space.  
• Nutritional supplements originally intended to keep astronauts fit and mitigate the health hazards of a long stay in space.  

As NASA continues advancing technology and research in low Earth orbit to establish a sustained presence at the Moon, upcoming lunar missions are already spinning off technologies on Earth. For example, Spinoff 2025 features a company that invented technology for 3D printing buildings on the Moon that is now using it to print large structures on Earth. Another group of researchers studying how to grow lunar buildings from fungus is now selling specially grown mushrooms and plans to build homes on Earth using the same concept.  

Spinoffs produce innovative technologies with commercial applications for the benefit of all. Other highlights of Spinoff 2025 include quality control on assembly lines inspired by artificial intelligence developed to help rovers navigate Mars, innovations in origami based on math for lasers and optical computing, and companies that will help lead the way to hydrogen-based energy building on NASA’s foundation of using liquid hydrogen for rocket fuel.  

“I’ve learned it’s almost impossible to predict where space technology will find an application in the commercial market,” said Dan Lockney, Technology Transfer program executive at NASA Headquarters in Washington. “One thing I can say for sure, though, is NASA’s technology will continue to spin off, because it’s our goal to advance our missions and bolster the American economy.”  

This publication also features 20 technologies available for licensing with the potential for commercialization. Check out the “Spinoffs of Tomorrow” section to learn more.

Spinoff is part of NASA’s Space Technology Mission Directorate and its Technology Transfer program. Tech Transfer is charged with finding broad, innovative applications for NASA-developed technology through partnerships and licensing agreements, ensuring agency investments benefit the nation and the world.  

To read the latest issue of Spinoff, visit: 

https://spinoff.nasa.gov

-end-

Jasmine Hopkins
Headquarters, Washington
321-432-4624
jasmine.s.hopkins@nasa.gov

The latest edition of NASA’s Spinoff publication, which highlights the successful transfer of agency technology to the commercial sector, is now available online.

For nearly 25 years, NASA has supported crew working in low Earth orbit to learn about the space environment and perform research to advance deep space exploration. Astronauts aboard the International Space Station have learned a wealth of lessons and tried out a host of new technologies. This work leads to ongoing innovations benefiting people on Earth that are featured in NASA’s annual publication.  

“The work we do in space has resulted in navigational technologies, lifesaving medical advancements, and enhanced software systems that continue to benefit our lives on Earth,” said Clayton Turner, associate administrator, Space Technology Mission Directorate at NASA Headquarters in Washington. “Technologies developed today don’t just make life on our home planet easier – they pave the way to a sustained presence on the Moon and future missions to Mars.” 

The Spinoff 2025 publication features more than 40 commercial infusions of NASA technologies including: 

• A platform enabling commercial industry to perform science on the space station, including the growth of higher-quality human heart tissue, knee cartilage, and pharmaceutical crystals that can be grown on Earth to develop new medical treatments.  
• An electrostatic sprayer technology to water plants without the help of gravity and now used in sanitation, agriculture, and food safety.  
• “Antigravity” treadmills helping people with a variety of conditions run or walk for exercise, stemming from efforts to improve astronauts’ fitness in the weightlessness of space.  
• Nutritional supplements originally intended to keep astronauts fit and mitigate the health hazards of a long stay in space.  

As NASA continues advancing technology and research in low Earth orbit to establish a sustained presence at the Moon, upcoming lunar missions are already spinning off technologies on Earth. For example, Spinoff 2025 features a company that invented technology for 3D printing buildings on the Moon that is now using it to print large structures on Earth. Another group of researchers studying how to grow lunar buildings from fungus is now selling specially grown mushrooms and plans to build homes on Earth using the same concept.  

Spinoffs produce innovative technologies with commercial applications for the benefit of all. Other highlights of Spinoff 2025 include quality control on assembly lines inspired by artificial intelligence developed to help rovers navigate Mars, innovations in origami based on math for lasers and optical computing, and companies that will help lead the way to hydrogen-based energy building on NASA’s foundation of using liquid hydrogen for rocket fuel.  

“I’ve learned it’s almost impossible to predict where space technology will find an application in the commercial market,” said Dan Lockney, Technology Transfer program executive at NASA Headquarters in Washington. “One thing I can say for sure, though, is NASA’s technology will continue to spin off, because it’s our goal to advance our missions and bolster the American economy.”  

This publication also features 20 technologies available for licensing with the potential for commercialization. Check out the “Spinoffs of Tomorrow” section to learn more.

Spinoff is part of NASA’s Space Technology Mission Directorate and its Technology Transfer program. Tech Transfer is charged with finding broad, innovative applications for NASA-developed technology through partnerships and licensing agreements, ensuring agency investments benefit the nation and the world.  

To read the latest issue of Spinoff, visit: 

https://spinoff.nasa.gov

-end-

Jasmine Hopkins
Headquarters, Washington
321-432-4624
jasmine.s.hopkins@nasa.gov