There has been a growing trend at legacy media organizations where progressive staffers ignite a war with their employers over an editorial position that does not align with their own. 

Among the most memorable clashes in recent years include the social media revolt by New York Times staffers over the infamous Tom Cotton op-ed in 2020 and the open attacks by CNN employees over the network's Trump town hall in 2023.

In 2024, that trend exploded across multiple news outlets. These were the biggest newsroom revolts of the year:

NBC News was engulfed in a firestorm fueled by its own staffers after the network announced in March it had hired former Republican National Committee chair Ronna McDaniel as a contributor.

The practice of major news organizations hiring ex-lawmakers, government officials and political insiders has existed for decades and has largely been non-controversial. But a chorus of NBC talent, particularly from its liberal cable arm MSNBC, publicly disavowed McDaniel's hiring, citing her alleged actions in trying to block the certification of Michigan's election results in 2020.

"We weren’t asked our opinion of the hiring, but if we were, we would have strongly objected to it for several reasons including, but not limited to, as lawyers might say, Ms. McDaniel’s role in Donald Trump’s fake elector scheme and her pressuring election officials to not certify election results while Donald Trump was on the phone," MSNBC's Joe Scarborough said on "Morning Joe." 

NBC'S CHUCK TODD EXPLODES ON NETWORK BOSSES ON THE AIR FOR HIRING RONNA MCDANIEL AS ANALYST, CALLS FOR APOLOGY

Rachel Maddow, MSNBC's biggest star, blasted NBC's "inexplicable" decision to hire McDaniel and expressed hope that the network would reverse its decision.

Several among the network's liberal talent, including Chuck Todd, Nicolle Wallace, Joy Reid and Jen Psaki, also spoke out against the move. Todd memorably fumed on "Meet the Press" after colleague Kristen Welker interviewed McDaniel, in what turned out to be her only appearance as a contributor.

"I think our bosses owe you an apology for putting you in this situation, because I don't know what to believe," he said.

MSNBC STARS SHOOT INSIDE THE TENT, ATTACK NBC FOR HIRING EX-RNC CHAIR RONNA MCDANIEL: ‘INEXPLICABLE’

Just four days after NBC News announced McDaniel's hiring, she was terminated. 

"There is no doubt that the last several days have been difficult for the News Group," NBCUniversal News Group Chairman Cesar Conde told staff in a memo. "After listening to the legitimate concerns of many of you, I have decided that Ronna McDaniel will not be an NBC News contributor."

Conde acknowledged McDaniel's hiring had undermined the goal of a "cohesive and aligned" newsroom and offered an apology to his staff. 

"I want to personally apologize to our team members who felt we let them down," Conde wrote. "While this was a collective recommendation by some members of our leadership team, I approved it and take full responsibility for it."

In October, the left-wing staff at CBS News lashed out at their colleague, "CBS Mornings" co-host Tony Dokoupil, over his tough but civil interview exchange with progressive author Ta-Nehisi Coates. 

Dokoupil, who is Jewish and has children living in Israel, grilled Coates, whose new book "The Message" is harshly critical of Israel and has been rebuked by the Jewish state's defenders for its shallow analysis of a complicated conflict.

"The content of that section would not be out of place in the backpack of an extremist," Dokoupil told Coates about one portion about his trip to Israel and the Palestinian territories, asking him "Why leave out so much" and "What is it that so particularly offends you about the existence of a Jewish state that is a Jewish safe place?" 

CBS HOST GRILLS TA-NEHISI COATES ON ANTI-ISRAEL VIEWS IN NEW BOOK: LOOKS LIKE IT CAME FROM AN ‘EXTREMIST’

CBS leadership reassured offended staff members that following a review, they concluded that the interview did not meet the company’s "editorial standards," the Free Press reported, which obtained audio of the staff meeting. 

While a source familiar with the matter told Fox News Digital that Dokoupil would not be punished over the interview, he was forced to meet with the network’s in-house Race and Culture Unit following complaints. According to The New York Times, the conversation "focused on Mr. Dokoupil’s tone of voice, phrasing and body language" during the interview.

The New York Post also reported that Dokoupil expressed regret to staffers at a meeting, with one network insider describing it, "There were tears. [People were] very upset."

Some have rallied in his defense, like CBS News legal correspondent Jan Crawford, who went to bat for him during a network conference call, and Shari Redstone, chair of CBS News' parent company Paramount Global, who called the network's handling of Dokoupil a "mistake." CBS CEO George Cheeks issued a memo standing by the news network's leadership. 

Some of the country's most prominent newspapers made their own headlines by ending their decades-long practice of endorsing presidential candidates. 

The Los Angeles Times kicked off the movement with a decision made by its owner, Dr. Patrick Soon-Shiong for the paper to not make any endorsement in the 2024 race. Upset that they couldn't formally put their support behind Vice President Kamala Harris, that led to a slew of resignations, including by Times editorials editor Mariel Garza and editorial board members Robert Greene and Karin Klein.

Times columnist Harry Litman offered his resignation in December, citing the paper's "shameful capitulation" to Trump after Soon-Shiong made overtures to moderate the paper, like bringing aboard conservative commentator Scott Jennings to its revamped editorial board. 

Days after the Times, The Washington Post announced it would no longer make endorsements in presidential races. The paper's billionaire owner Jeff Bezos halted the editorial board's planned endorsement of Harris as well – the Post had endorsed the Democrat in every presidential election since 1976 except for when it omitted any endorsement at all in 1988.

That move sparked an avalanche of outrage from the Post's union to its prominent columnists, 20 of whom signed an open letter denouncing the paper's decision. Multiple editorial board members stepped down, and the Post's editor-at-large Robert Kagan resigned. 

Not only did the Post suffer internal bleeding, it sparked a boycott movement among its liberal readers. The paper reportedly lost 250,000 paid subscribers as a result, and it was already on track to lose $77 million this year. 

WAPO STAFFER UNSURE PAPER CAN RECOVER AS BEZOS-OWNED OUTLET SHEDS 250,000 SUBSCRIBERS OVER ENDORSEMENT FIASCO

Bezos penned an op-ed defending the decision, citing growing distrust in the media. 

"We must be accurate, and we must be believed to be accurate. It’s a bitter pill to swallow, but we are failing on the second requirement," Bezos wrote. "Most people believe the media is biased. Anyone who doesn’t see this is paying scant attention to reality, and those who fight reality lose. Reality is an undefeated champion. It would be easy to blame others for our long and continuing fall in credibility (and, therefore, decline in impact), but a victim mentality will not help. Complaining is not a strategy. We must work harder to control what we can control to increase our credibility."

"By itself, declining to endorse presidential candidates is not enough to move us very far up the trust scale, but it’s a meaningful step in the right direction. I wish we had made the change earlier than we did, in a moment further from the election and the emotions around it. That was inadequate planning, and not some intentional strategy," Bezos later conceded. 

As in any business, stars can experience highs and lows.

While one celebrity may struggle to make ends meet one year, the next they could be at the pinnacle of their career. Likewise, someone at the top of their game could easily lose everything.

Fox News Digital takes a look at celebrities who dominated 2024, as well as those who experienced major lows.

TAYLOR SWIFT'S ‘FAKE’ RELATIONSHIP, PRINCE HARRY'S DIVORCE: CELEBRITIES SHUT DOWN WILDEST RUMORS OF 2024

"Yellowstone" creator Taylor Sheridan has had a banner year in 2024 as the beloved Western series made a triumphant comeback after a long break.

The show returned in November with six new episodes, the second half of its fifth season, which had last aired in January 2023. Although the show's star, Kevin Costner, bowed out early, his character not appearing in the new episodes, fans tuned in in record-breaking numbers. The finale, which aired on Dec. 15, was the most-watched episode in the show's history, per Variety.

Aside from "Yellowstone," Sheridan also continued to expand his TV empire with his new show, "Landman," starring Billy Bob Thornton. His shows "Lioness," "Tulsa King" and "Mayor of Kingstown" continued this year as well, and another spin-off of his beloved western series called "The Madison" was announced.

Taylor Swift continued her reign as one of the world's biggest pop stars this year, taking her massively popular "Eras" tour overseas before returning to North America. In December, she played her last show of the tour in Vancouver.

TAYLOR SWIFT ‘ERAS TOUR’ ENDS: 8 MOMENTS THAT LEFT FANS SHOCKED

Following the conclusion of the tour, she authorized the release of the financial numbers, with the New York Times reporting that she raked in over $2 billion – double the amount of any other gross ticket sales of a concert tour.

In addition to the "Eras" tour, Swift released a new album, "The Tortured Poets Department," which broke a number of sales and streaming records. On a more personal note, her relationship with Kansas City Chiefs tight end Travis Kelce appears to be going stronger than ever, with many fans urging him to propose.

2024 wasn't just a good year for mega-stars like Swift: Women in pop music continually dominated the charts.

Chappell Roan has been making music for years, but it wasn't until this summer that she became a full-fledged pop star. After a notable appearance on NPR's Tiny Desk and the release of her single "Good Luck Babe!" she was invited to perform at Coachella in April. Her performance went viral.

A song that she released last year, "HOT TO GO!" also started receiving massive radio play, and her concerts began bringing in bigger and bigger crowds.

Roan won her first MTV Video Music Award for Best New Artist in September, and in December she won a Billboard Music Award for Top New Artist. She's nominated for six Grammy Awards, including record of the year.

Former Disney star Sabrina Carpenter made herself a household name as well with platinum hits like "Espresso," "Please Please Please" and "Taste." Like Roan, she's also nominated for six Grammy Awards.

Billie Eilish soared to the top of the charts with the release of her April album "Hit Me Hard and Soft." She won her second Academy Award for best original song with "What Was I Made For?" the song she wrote for "Barbie," and in November, she embarked on a world tour.

While historically, young ingénues have thrived in Hollywood, this year has seen a number of movies featuring more seasoned actresses in roles with sex appeal.

Nicole Kidman, 57, notably starred in the recently released "Babygirl," an erotic thriller that sees Kidman's character having a steamy affair with a decades-younger man.

‘THE SUBSTANCE’ STAR DEMI MOORE SAYS ‘INSECURITIES ABOUT MY BODY’ LED HER TO TAKE ON RACY ROLES

Meanwhile, Demi Moore, 62, took on a daring role in the body horror flick "The Substance." In the movie, which premiered in September, she appears nude, with a particular shot showing off her behind at a less-than-flattering angle – something that she confessed to Elle "bugs the s--- out of" her to see. Still, she chose not to ask for the shot to be altered because "I knew it was in service of something that was more important than me."

She added, "There was an incredibly liberating aspect to stepping into this really vulnerable, exposed place emotionally and physically."

In December, Pamela Anderson made a remarkable achievement in earning her first-ever Golden Globe nomination for her work in "The Last Showgirl." For the actress, who rose to fame for starring as blonde bombshell C.J. Parker in "Baywatch," it was a dream come true.

"It is never too late to dream, to start again, to stay open to possibilities — we are not all so lucky," she shared in a statement after being nominated for best performance by a female actor in a motion picture.

Jelly Roll was already a country star at the beginning of the year, but for the past 12 months, his career has only gotten hotter.

He followed up his wildly successful "Whitsitt Chapel" album with October's "Beautifully Broken," his first No. 1 album in the U.S. He also performed as the musical guest for the season premiere of the historic 50th season of "Saturday Night Live."

But it wasn't just the music that made 2024 a notable year for Jelly Roll – he's also made big strides with his weight loss, sharing in November that he'd officially lost 100 pounds in his weight-loss journey.

While these stars dominated 2024, others faced very public struggles.

In September, after a number of civil suits were filed against him, Sean "Diddy" Combs was arrested in New York by federal agents on sex trafficking and racketeering charges.

While Combs has maintained his innocence, he's remained in jail as he awaits his trial, which is set to begin on May 5, 2025. He and his legal team have requested bail multiple times, and each time it's been denied, with judges expressing concern that he'd potentially tamper with witnesses if released.

Combs is facing 15 years to life in prison if convicted of his charges.

SEAN ‘DIDDY’ COMBS TOPPED CELEBRITY SCANDALS OF 2024

In the months after the initial arrest, more allegations have been made against the rapper. Most recently, he was hit with a $15 million lawsuit in December by a woman named LaTroya Grayson, who attended a "Black Party" hosted by Combs in 2006. Grayson claimed that Combs drugged and sexually assaulted her at the party, while his lawyer calls those claims "pure fiction."

In one lawsuit against Combs, an anonymous accuser claimed that Combs raped her at an MTV VMAs after-party in 2000, when she was 13 years old. She also claimed that an unnamed male celebrity raped her as well, and that an unnamed female celebrity was present during the alleged assaults. The suit was re-filed in December, with Jay-Z named as the male celebrity. The female celebrity has not been named.

Jay-Z has strongly denied the accusation, and his legal team has gone on the offensive, filing to dismiss the lawsuit and also requesting that the accuser's name be made public.

New York Judge Analisa Torres ruled against Jay-Z last week, saying in part that his lawyer's "relentless filing of combative motions containing inflammatory language and ad hominem attacks is inappropriate, a waste of judicial resources, and a tactic unlikely to benefit his client."

BEYONCÉ JAY-Z SOLIDARITY AMID DIDDY LAWSUIT NO SURPRISE AFTER CHEATING RUMORS, FAMILY ELEVATOR FIGHT

While Jay-Z faces legal woes, Beyoncé, his wife of 16 years, has seen some controversy of her own in 2024.

In March, she released "Cowboy Carter," her first country album, to mixed reviews. While some praised her for her take on the genre, others criticized the album, with some even suggesting that it's a mockery of country music.

She also made waves for her performance at the halftime show of the Christmas Day football game between the Houston Texans and the Baltimore Ravens. At one point during the show, she made a finger-gun gesture – something that's been banned by the NFL.

BEYONCÉ'S FINGER-GUN GESTURE DURING NFL HALFTIME SHOW SPARKS JOKES AMONG FANS

Players have been given fines for making the gesture, and some fans wondered if Beyoncé would be given the same treatment.

This month, Blake Lively filed a complaint with the California Civil Rights department, alleging that Justin Baldoni, her co-star and director in "It Ends with Us," sexually harassed her.

The complaint, a precursor to a lawsuit, accused Baldoni of harassing her during the filming of the movie and included notes on a meeting held to discuss the "hostile work environment that had nearly derailed production." During the meeting, Lively allegedly requested that Baldoni stop adding sex scenes that were not originally in the script, that he stop talking about his genitals, stop showing nude videos and photographs to her and more.

Additionally, Lively named Baldoni's publicists in the complaint, claiming that they created and implemented a smear campaign to destroy her reputation with the intent of harming her credibility if she ever went public with the allegations.

In a statement given to the New York Times, Lively said, "I hope that my legal action helps pull back the curtain on these sinister retaliatory tactics to harm people who speak up about misconduct and helps protect others who may be targeted."

Bryan Freedman, an attorney for Baldoni, told the outlet, "These claims are completely false, outrageous and intentionally salacious with an intent to publicly hurt and rehash a narrative in the media."

Freedman recently told People magazine he plans to "expose" the "false" narrative created by Lively's legal complaint against Baldoni.

The actor's lawyer told the outlet the impending lawsuit "is not a response or countersuit – it’s a deliberate pursuit of truth."

In November, country star Zach Bryan was accused by his ex-girlfriend, Brianna "Chickenfry" LaPaglia, of emotional abuse.

LaPaglia, an internet personality, spoke about her relationship with Bryan on the "BFFs" podcast, which she co-hosts with Dave Portnoy and Josh Richards. She said in part, "The last year of my life has been the hardest year of my life, dealing with the abuse from this dude. I’m still scared right now because I’m scared of him still, my brain’s rewired. I’m scared to make him mad."

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In addition to the claims of abuse, she alleged that Bryan had offered her a $12 million nondisclosure agreement to keep her from discussing details of their relationship. On refusing the NDA, she said, "I don’t want in two years to buy a f---ing house and think, ‘Oh, this is the money from the dude that literally f---ing destroyed me and broke me for a year?’ F--- that, f--- you, I don’t want your money."

Bryan hasn't commented on the accusations. In a later episode of her podcast, LaPaglia said his silence is "deafening."

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Following his rise to fame as the drummer for Nirvana, Dave Grohl has spent decades in the spotlight. Going on to lead his own highly successful band, the Foo Fighters, Grohl has cultivated a charming, relatable persona.

Because of that, it was especially shocking to many fans when, in September, he shared a statement admitting to fathering a child with someone other than his wife.

"I've recently become the father of a new baby daughter, born outside of my marriage," a statement posted to his social media read. "I plan to be a loving and supportive parent to her. I love my wife and children, and I am doing everything I can to regain their trust and earn their forgiveness."

He finished, "We are grateful for your consideration toward all the children involved, as we move forward together."

Grohl and his wife, Jordyn Blum, have been married since 2003. They share three daughters: Violet, 18, Harper, 15, and Ophelia, 10.

In 2024, President-elect Donald Trump managed to earn the support of many high-profile figures – entertainers, athletes, podcasters and executives – who openly aligned themselves with the Make America Great Again message this year and challenged the seemingly insurmountable blue wave of stars who remain Trump cynics.

What was once a rare phenomenon in liberal-leaning Hollywood seemed to become some semblance of mainstream, raising questions about the shifting cultural dynamics in the deep blue bastion and the role of political partisanship in shaping public perception.

From the red carpet to red MAGA hats, these Trump-supporting celebrities set their hearts on Making America – and perhaps Hollywood – Great Again in 2024 and beyond. 

TRUMP'S VICTORY: HOLLYWOOD ELITE WHO VOWED TO LEAVE US IF HE WON ARE  ‘ALL TALK, NO WALK,' EXPERT SAYS

Elon Musk unveiled his now-iconic "Dark MAGA" hat while energizing Trump supporters in Butler, Pennsylvania, three months after gunman Thomas Matthew Crooks made the first attempt on the then-presidential candidate's life at the site.

The billionaire entrepreneur, who has long defied conventional norms, "fully" endorsed Trump after the Butler shooting on July 13, posting a clip of the incident on X, formerly Twitter, along with his message of support.

He launched a pro-Trump super PAC, spoke at Trump's massive rally at New York City's iconic Madison Square Garden just before the election, and even agreed to take an active role in his incoming administration by co-leading the newfound Department of Government Efficiency (DOGE) alongside Vivek Ramaswamy. 

With the changing of the guard next month, the entrepreneurial duo looks to streamline government processes, cutting out wasteful spending and downsizing a bloated bureaucracy. 

Illustrious podcaster Joe Rogan shocked many when he publicly endorsed Trump on the eve of the 2024 election, crediting Elon Musk for his "compelling case" for then-candidate Trump. 

"The great and powerful @elonmusk. If it wasn't for him we'd be f---ked. He makes what I think is the most compelling case for Trump you'll hear, and I agree with him every step of the way. For the record, yes, that's an endorsement of Trump. Enjoy the podcast," Rogan wrote.

Known for his candid opinions and immense influence, Rogan's last minute endorsement dealt a significant blow to the Harris campaign, which had already struggled to secure a number of key endorsements.

Both Trump and Vice President-elect JD Vance made appearances on Rogan's podcast before the Nov. 5 faceoff, with Trump's funny and authentic demeanor impressing the host. Harris reportedly had plans to sit down with Rogan for an interview as well, but her campaign's insistence that the interview last only one hour – and that Rogan travel to meet her – never worked out.

"Trumpamaniacs" filled the Fiserv Forum at this year's Republican National Convention in Milwaukee, Wisconsin – their cheerleader, WWE legend Hulk Hogan, taking to the stage to show his support shortly after the Butler, Pennsylvania shooting.

Hogan stood on stage in a dark shirt branded with his "Real American Beer" logo under a dark jacket, but he proceeded to take off the latter and rip off the former in true pro-wrestling fashion, revealing a red Trump-Vance shirt.

"Enough was enough, and I said, let Trump-a-mania run wild, brother. Let Trump-a-mania rule again. Let Trump-a-mania make America great again," he shouted. 

"I’ve seen some great tag teams in my time – Hulk Hogan and oooh, yeah, the ‘Macho Man’ Randy Savage. But you know something? I see the greatest tag team of my life standing upon us and getting ready to straighten this country out for all the real Americans," he added. 

The wrestling icon also pumped up the crowd at Trump's Madison Square Garden rally in October, where he tore into Harris for her mishandling of the southern border crisis and praised Trump as the "only man that can fix this country today."

YouTuber-turned-boxer Jake Paul opened up about his support for Trump in October, taking to social media to announce that he had essentially "rescinded" his right to vote in the then-upcoming presidential election by moving to Puerto Rico, but he wanted to make his voice heard somehow.

Paul said he was "nervous" to make the video and weighed how it might impact his career. He proceeded to criticize the current trajectory of the nation that has largely remained under Democratic control for 12 of the last 16 years, asking, "So, if we aren’t happy with the current political state, economic state, environmental state, then who is to blame?" 

"Do the right thing, vote for Donald Trump. Not because I said so, not because Beyoncé said so, but because it’s what’s right… Please, go, for the love of God, go exercise your right to vote on my behalf and vote for Donald Trump in this election. America depends on it," he said.

Paul celebrated Trump's win over Harris shortly after the Fox News desk projected the victory, saying, "The truth and God won in America."

Packers quarterback legend Brett Favre made the crowd roar at the Resch Center in Green Bay, Wisconsin when he spoke out in support of Trump, likening him to the Packers organization by calling him a "winner."

"The United States of America won with his leadership," he told the crowd.

Favre took on an imperative tone as he spoke of the Nov. 5 election, warning that "there’s never been a more important time in our lives than right now."

He also spoke in a language many easily understood, his words rife with football analogies and references to the team that voters in the key swing state adore. He mentioned the definition of insanity – doing the same thing repeatedly while expecting a different result.

"Sounds like the first couple of years of my tenure here with the Packers," he joked. "Mike Holmgren would say, ‘What in the hell are you doing, Brett?’ I said, ‘Hell, I don’t know, Mike.’ But we figured out a way to get it done."

Tethering the example to the Biden-Harris administration, he added, "It would be insane to give Kamala four more years in office."

Former NASCAR driver Danica Patrick voted for the first time ever in the 2024 presidential election, casting her ballot for Donald Trump. 

Patrick, who remains the only woman to win an IndyCar Series race in history, discussed her decision on "Jesse Watters Primetime" in October and speculated that many women reluctant to vote for Trump may have had an issue with his personality. 

"It feels like voting for Donald Trump is like the vote of reason. It’s like the rational, reasonable choice," she said.

"I feel like most of all, though, what this country could be if he gets into office, with all the amazing, brilliant people who are supporting him, I feel like it can not only make America great again, but make America greater than it’s ever been," she added later.

The formerly apolitical racecar driver began paying close attention to the news earlier this year and developed her opinions. She showed her support for the Trump-Vance ticket prior to her discussion with Watters, hosting a Q&A session with Vance in Greensboro, North Carolina in October.

Patrick even made appearances at Trump-related events such as a Trump Team women's tour stop in Atlanta, Georgia and a rally in Lititz, Pennsylvania.

Finding rapper and formerly-adamant Trump opponent Amber Rose on stage at any GOP-related event might have seemed unthinkable to some, yet her smile beamed at the crowd as she spoke to delegates and spectators at this year's Republican National Convention.

Her purpose? Explaining how Trump had earned her support.

"I realize Donald Trump and his supporters don’t care if you’re Black, White, gay or straight, it’s all love. And that’s when it hit me, these are my people. This is where I belong," the TV personality said.

Critics on both sides of the aisle hurled insults her way before and after she took the stage, with some conservatives criticizing her for being not conservative enough and some liberal voices calling out the alleged bid to recruit more minority voters.

Not all were critical of her presence, however.

ESPN host Stephen A. Smith came to her defense amid the criticism, saying, "I know that Amber Rose took a lot of hits. Y’all kick rocks with that. She did a good job. She did a good job."

Young conservative Xaviaer DuRousseau said that Rose's addition to the guest list offered evidence that the 2024 RNC would be a "historic event." 

"Amber Rose is one of many Black Americans who finally woke up from the Left's lies after doing her own research about President Trump," he said.

"Reagan" star Dennis Quaid rallied for Trump in Coachella, California weeks before Election Day, telling voters "it's time to pick a side" while comparing and contrasting Trump and Harris' visions for the future.

"Are we going to be a nation that stands for the Constitution? Or for TikTok? Are we going to be a nation of law and order? Or wide open borders? Which is it? Because it's time to pick a side," he said, donning a MAGA hat.

With record-high inflation, hostages in the Middle East and an apparent blanket of malaise over the U.S., he likened the 2024 race to the 1980 faceoff between Ronald Reagan and then-Democratic President Jimmy Carter. 

"I'm going to ask you a question that Reagan asked America back then, and I think it's the question that got him elected. Are you better off than you were four years ago?" Quaid said. 

Earlier this year, Quaid applauded Trump for paying visits to New York neighborhoods after his rally in the South Bronx, suggesting that the move made him appear "more human" to people.

"Sopranos" star Drea de Matteo may call herself a "liberal," but, in her eyes, the "mean-spirited" nature that has possessed the progressive left falls short of the way things should be.

"Say what you want about Trump, and I understand that a lot of people have Trump Derangement Syndrome," she said. "I was one of them. But people can change. And it's not that Trump changed, I changed, and I did my research, and I paid more attention to what was going on."

She criticized celebrities who openly mocked the July assassination attempt against Trump, including "Star Wars" star Mark Hamill and Kyle Gass, a bandmate of actor and musician Jack Black.

"Everybody has their right to their opinion, and they have freedom of speech, so here we are," she told Fox News Digital. "But, again, I'm a liberal. I am a liberal who does not understand how the left has become so rebellious, with not one undertone of peace, love, harmony and compassion. You're supposed to be the party of inclusivity, of love, of peace. And all of a sudden, these are the rioters. These are the mean-spirited folks out there. And I don't understand that."

She called for celebrities who are vehemently opposed to Trump to do some internal reflecting, to ask themselves "why they're so filled with rage."

Comedian, actor and podcaster Russell Brand has been notoriously outspoken, challenging the system and vehemently opposing censorship.

He sounded off on the 2024 election earlier this year, picking Trump as the better candidate for preserving democratic values.

"In a straight choice between Donald Trump and Joe Biden, if you care about democracy, if you care about freedom, I don’t know how you could do anything other than vote for Donald Trump for precisely the reasons that they claim that you can’t," he told RNC spokeswoman Elizabeth Pipko during a June clip of the "Stay Free with Russell Brand" podcast, obtained by Fox News Digital at the time.

President Biden was still a contender in the race at the time, later passing the torch to Vice President Kamala Harris after a debate performance that was widely considered poor.

Brand was also in Milwaukee for this year's Republican National Convention, according to the Milwaukee Journal Sentinel, and was recently spotted at Trump's Mar-a-Lago estate in Florida.

"Shazam!" star Zachary Levi also endorsed Trump this year, revealing the decision while moderating an event in Michigan with former presidential candidate Robert F. Kennedy Jr. and former Hawaii Rep. Tulsi Gabbard – now both Trump cabinet nominees.

"We are going to take back this country. We are going to make it great again, we're going to make it healthy again. And so I stand with Bobby and I stand with everyone else who is standing with President Trump," Levi said in September. 

"Of the two choices that we have, and we only have two, President Trump is the man that can get us there." 

Levi refuted claims that his career had suffered following his Trump endorsement, telling HBO's Bill Maher that it's still "full steam ahead" for several in-progress projects, though he did not yet know what the "ultimate effects" of the endorsement might be.

Fox News' Cortney O'Brien, Alexa Moutevelis, Alexander Hall, Yael Halon, Paulina Dedaj, Scott Thompson, Danielle Wallace, Joshua Q. Nelson, Gabriel Hays, Gabriele Regalbuto, Charles Creitz and Ryan Gaydos contributed to this report.

The presidential election generated numerous high-profile political gaffes this year, including President Biden’s widely-panned debate performance and him calling Trump supporters "garbage" in the closing days of Vice President Kamala Harris’ campaign. 

Here are six of the biggest political gaffes of 2024: 

A disastrous performance by President Biden during his debate with former President Trump on June 27 appeared to be the beginning of the end for Biden's 2024 re-election campaign. 

He struggled with a raspy voice and delivered rambling answers during the debate in Atlanta, sparking doubts about his viability at the top of the Democratic Party’s presidential ticket. 

KARINE JEAN-PIERRE'S MOST MEMORABLE MOMENTS OF 2024 

Biden’s campaign blamed the hoarse voice on a cold and the 81-year-old admitted a week later that he "screwed up" and "had a bad night," yet that didn’t stop a chorus of Democrats from making calls for him to drop out of the race. 

In a shocking move, Biden then pulled the plug on his campaign on July 21 and endorsed Harris, who would go on to lose to Trump in November. 

Biden appeared to galvanize Republicans when he called Trump supporters "garbage" less than a week before Election Day. 

Trump’s rally in Madison Square Garden in New York City on Oct. 27 made headlines when a comedian mocked different ethnic groups, calling Puerto Rico a "floating island of garbage." 

Then, during a conference call with the Voto Latino group on Oct. 30, Biden said, "The only garbage I see floating out there is his supporters."  

Biden and the White House then tried to clean up his words in the days afterward. However, the remark was quickly likened to Hillary Clinton’s labeling of half of Trump supporters as belonging in "a basket of deplorables" in 2016, a comment that was widely seen as undermining her campaign. 

Vice President Kamala Harris’ answer to a question during an Oct. 8 appearance on "The View" may have been a turning point in the 2024 presidential election. 

Co-host Sunny Hostin asked Harris, "If anything, would you have done something differently than President Biden during the past four years?" Harris paused for a moment and then said, "There is not a thing that comes to mind in terms of — and I’ve been a part of most of the decisions that have had impact." 

TOP POLITICAL COURTROOM MOMENTS OF 2024 

Hostin had given Harris a clear opportunity to differentiate herself from Biden, but Harris instead effectively cut an ad for Trump's campaign by allowing it to tie her directly to an unpopular administration. 

Harris’ running mate Tim Walz raised eyebrows during his vice presidential debate with Sen. JD Vance, R-Ohio, on Oct. 1, when he declared he had "become friends with school shooters." 

The poorly timed mishap occurred when the Minnesota governor was asked about changing positions on banning assault weapons.

"I sat in that office with those Sandy Hook parents. I’ve become friends with school shooters. I’ve seen it," Walz said. 

Walz presumably meant he had become friendly with parents who lost children during horrific school shootings. 

Trump appeared to confuse then-Republican presidential primary opponent Nikki Haley with former House Speaker Nancy Pelosi during a rally in New Hampshire on Jan. 20.

Speaking in Concord, Trump said that Haley, his former ambassador to the United Nations, had been responsible for the collapse of Capitol Hill security during the Jan. 6, 2021, riot. Trump has previously blamed Pelosi for turning down National Guard support before the riot. 

"You know, by the way, they never report the crowd on January 6, you know, Nikki Haley. Nikki Haley, Nikki Haley, you know, they — did you know they destroyed all the information and all of the evidence. Everything. Deleted and destroyed all of it, all of it, because of lots of things, like Nikki Haley is in charge of security. We offered 10,000 people, soldiers, National Guard. So whatever they want, they turned it down. They don't want to talk about that. These are very dishonest people," Trump said. 

Harris found herself in the headlines repeatedly this year for making confusing verbal statements. 

"I grew up understanding the children of the community are the children of the community, and we should all have a vested interest in ensuring that children can go grow up with the resources that they need to achieve their God-given potential," the vice president once said in September. 

"We are here because we are fighting for a democracy. Fighting for a democracy. And understand the difference here, understand the difference here, moving forward, moving forward, understand the difference here," she then said at a campaign event in November. 

The remarks drew criticism and ridicule from conservatives online. 

President Biden mistakenly introduced Ukraine President Volodymyr Zelenskyy as "President Putin" during a NATO conference in Washington, D.C., in July.

"And now I want to hand it over to the president of Ukraine, who has as much courage as he has determination," Biden said, before starting to leave the podium. "Ladies and gentlemen, President Putin." 

"He’s going to beat President Putin. President Zelenskyy. I’m so focused on beating Putin," Biden then said, appearing to realize the verbal stumble. "We got to worry about it. Anyway, Mr. President." 

Fox News’ Paul Steinhauser, Joseph A. Wulfsohn, Jacqui Heinrich, Sarah Rumpf-Whitten, David Rutz, Brian Flood and Chris Pandolfo contributed to this report. 

Jennifer Lopez and Ben Affleck's love story was two decades in the making, but the former couple ultimately went their separate ways. 

Lopez and Affleck, who tied the knot in 2022 after calling off their first engagement in 2002, were among the celebrity couples who made headlines this year with their shocking splits. 

While the notoriously private Oscar-winner, 51, has stayed silent on their split, the "On the Floor" hitmaker, 55, has been vocal about the end of her fourth marriage, telling Interview magazine in October that she was experiencing the "hardest time of my life" amid their "f------ hard breakup."

JENNIFER LOPEZ ADMITS THERE ARE 'NO COINCIDENCES' IN LIFE AFTER BEN AFFLECK DIVORCE

Lopez and Affleck are far from the only celebrity couple who called it quits. Here's a look back at the star separations of 2024.

Jennifer Lopez and Ben Affleck's highly-publicized romance came to an end over the summer after rumors of a split had been swirling for months.

Lopez filed for divorce from Affleck on Aug. 20 on the two-year anniversary of the former couple's Georgia wedding ceremony. 

The "Atlas" star cited "irreconcilable differences" as the reason for their split, according to documents obtained by Fox News Digital.

Lopez listed their date of separation as April 26 and additionally stated that she did not want either herself or Affleck to be awarded spousal support, according to court documents.

Affleck and Lopez were first engaged in 2002 after meeting on the set of "Gigli." Affleck proposed, and they were engaged to be married in 2004, but the wedding was called off at the last minute.

JENNIFER LOPEZ, BEN AFFLECK DIVORCE FILING SHOWS POWER PLAY, BUT EXPERT WARNS 'GLOVES MIGHT COME OFF'

Twenty years later, Lopez and Affleck married in Las Vegas during a surprise wedding ceremony and tied the knot again a month later in Georgia. 

Cyrus and Firerose, known legally as Johanna Hodges, married in October 2023. Several months later, in May, Cyrus filed for an annulment, citing "irreconcilable differences" and alleged "inappropriate marital conduct" in documents obtained by Fox News Digital. 

Since then, the couple has been engaged in a tumultuous online battle, including allegations of abuse and fraudulent spending.

Fox News Digital obtained shocking audio between Cyrus and his estranged wife where the country crooner is heard berating his Australian ex and using profane language.

"Hell yeah I was at my wit's end. As every day went by, I started realizing something was wrong. And that’s before I knew she was a fraud. I just knew something wasn’t right. That was before I knew she was David Hodges ex-wife," he said in a statement to Fox News Digital.

"That’s before I knew her parents last name. I had no idea she was arrested for felony residential burglary. I saw before my very own eyes, everything I thought I knew about her, was a lie. She was trying to take over my career, my life and usurp the Cyrus name for her own gain."

"See you in court," he ended the statement, which he also put on his Instagram Story.

In the recording, the former couple can be heard arguing about leaving for a presumed gig of Cyrus', which leads to some profanity, including calling her a "a selfish f---ing b----."

BILLY RAY CYRUS CLAIMS EX FIREROSE 'PHYSICALLY,' 'VERBALLY AND EMOTIONALLY' ABUSED HIM DURING THEIR MARRIAGE

Cyrus also claimed that estranged wife Firerose was "physically," "verbally and emotionally" abusive to him during their seven-month marriage in a court filing obtained by Fox News Digital. 

The country star also denied Firerose’s previous accusations made in a counter-suit that he abused her. 

The 62-year-old claimed in the filing that he only found out that Hodges wasn’t Firerose's "maiden name" after they were married, accusing her of lying to him in order to marry him. 

It said that Firerose only married him "with the sole intention of inducing Plaintiff into a marriage to obtain the name ‘Cyrus’ under the belief it would help her fledgling music career."

Cyrus added that he found her accusations of abuse "mindboggling" and called her "expectation" that they would ever perform together again or be "involved in any way professionally" in the future "comical."

In her countersuit after Cyrus' annulment filing, Firerose's legal team claimed, "Wife was the victim of extreme verbal, emotional, and psychological abuse. Wife was subjected to Husband’s persistent drug use accompanied with the consumption of marijuana which made Husband unpredictable and volatile towards Wife."

Cyrus and Firerose finalized their divorce three months after the country star petitioned for an annulment in August 2024, Fox News Digital confirmed.

Neither party was awarded alimony, and both parties agreed there are no jointly listed retirement assets.

"This past Friday the parties reached a settlement agreement at mediation to dissolve their 7-month marriage, and the Court declared the parties divorced this morning," Cyrus' rep said in a statement at the time. "Mr. Cyrus is relieved to put this nightmare behind him."

Spelling, who filed for divorce in March 2024, previously stated on her podcast, "missSPELLING," that the "final blow" came last year after an argument in their kitchen while McDermott was drunk. 

"He said, 'Ugh, I'm so sick of this. I have been picking up Tori Spelling's s--- for 18 years.' And I f---ing lost it," Spelling recalled.

Picking up right where she left off in the new episode, Spelling said, "This guttural scream came out of me…it was beast-like, it wasn’t pretty at all…I was like f--- you!" 

TORI SPELLING FILES FOR DIVORCE FROM DEAN MCDERMOTT AFTER 18-YEAR MARRIAGE

The argument continued, and according to Spelling, McDermott told her he wanted a divorce. He had "threatened it a million times," she noted, but she said "fine."

Spelling admitted she thought it was just another fight, but "all of a sudden, it was on Instagram."

Both she and their daughter, Stella, asked McDermott to remove the post, which he did the next day, but the public damage was done. 

The fight occurred on a Friday, and the following Monday, Spelling and her children were out of the house, which she had previously discussed having a mold problem. Meanwhile, she helped McDermott find rehab.

"He’s been sober since June 2023, and I’m very proud of him. We’ve been down this road before, no one really publicly knew, and I hope for him and the kids, that it sticks. I really do," she said at the time.

The couple married in 2006 and have five children together: Liam, Finn, Beau, Stella and Hattie. 

In the divorce filing documents, the date of separation for the couple is listed as June 17, 2023, close to the same day McDermott shared a now-deleted Instagram post announcing their separation. 

Since their separation, Spelling has been spotted sharing a kiss with advertising executive Ryan Cramer, and McDermott has been spending time with his new girlfriend, Lily Calo.

"We do now have family dinners with Dean and his girlfriend," Spelling shared. "I like her a lot. I like Lily a lot. It's not bad, it’s just different." 

As for the divorce filing, Spelling hopes it is "amicable."

"We’re co-parenting very well right now. The kids see him again, and they’re happy with his progress and the work he’s done on himself, and they’re proud of him, and we like his girlfriend, and we all co-parent together."

She continued, "You hope it works out like that, you always hope that. I don’t know, I don’t know what’s going to happen now, because it’s out of our hands, and it’s going to be with lawyers and courts, and I think they’re not quite always used to things not getting messy with celebrities. I don’t think either of us want it to get messy. Life’s messy."

In the divorce filing documents, Spelling is requesting spousal support while denying offering spousal support to McDermott. She also requested full physical custody and joint legal custody, with visitation rights for McDermott.

The former couple's split has become increasingly acrimonious and Haack has frequently slammed her ex on social media.

Haack and Hall secretly married in October 2021 and tied the knot again in September 2022 during a ceremony in Hawaii.

When they filed for divorce, Hall cited their date of separation as July 8, while Haack noted the former couple had separated the day before, on July 7.

Since filing for divorce, Haack has accused her estranged husband of transferring $35,000 of her money into his personal bank account on July 8 after their divorce filing, according to court documents obtained by Fox News Digital.

"I would not have asked him to send himself my money the day after I told him we are getting divorced," she stated in the documents.

In his divorce filing, Hall requested spousal support from Haack. In her latest court filing, Haack stated that her ex "should not need" spousal support as he has his own source of income. 

CHRISTINA HALL CRIES AS SHE TELLS EX-HUSBAND TAREK EL MOUSSA THEIR CHILDREN ASKED HER TO LEAVE EX JOSH HALL

The HGTV star's lawyer claimed in an Oct. 10 legal filing obtained by Fox News Digital that the request was "outrageous" because Hall is "self-supporting." The court documents were filed in response to Hall's attempt to block the sale of Haack's Tennessee home amid the former couple's ongoing divorce.

Last month, Hall filed a motion to stop the "Christina on the Coast" star from selling a Tennessee home that she had listed for $4.5 million, according to court documents. Hall has been living at the house since their split in July.

"Time to go back to reality soon... Remember when you said you would never steal from me or my kids and you would just be happy in a van with your dog? I guess plans changed," Haack said in a social media post, with a thinking face emoji.

"All about trying to take everything you can... With your mind on my money and my money on your mind...," she wrote, adding a money bag emoji.

Meanwhile, Hall slammed the legal filing in a statement shared on social media.

"So now @dearmeylaw files legal declarations with lies and assumptions… interesting tactic for someone who is a licensed attorney and took an oath of integrity," he wrote on his Instagram story. "Pretty sure making provably false statements to a judge is unethical."

"I prefer privacy, especially during something as life-changing as a divorce I did not ask for," he wrote. "I will not publicly badmouth anyone as people have families, friends and others who respect and love them. Unfortunately, the internet is forever."

"We are real humans, this is our life and I am not here to entertain people I don’t know with my private matters. Those details will be handled fairly behind closed doors with our respective counsels in due time. Those who know each of us, know who we are."

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"The Golden Bachelor" couple signed a dissolution of marriage decree in April in an Indiana court, Fox News Digital confirmed. 

A marital settlement agreement was issued, but terms of the order were not disclosed.

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Their split appeared to be largely due to not being able to settle into a permanent living situation as Nist is based in New Jersey, while Turner has called Indiana home.

Turner and Nist revealed that love simply wasn't enough to keep their marriage going during a joint interview on "Good Morning America" in April.

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"We looked at homes in South Carolina. We considered New Jersey. And we just looked at home after home, but we never got to the point where we made that decision," Nist said.

Turner added, "I still love this person. There’s no doubt in my mind I still am in love with her. I root for her every day."

Nist agreed, "Yeah, I still love him."

Nist recently appeared on "The Ben And Ashley I Almost Famous Podcast" and admitted that wasn't the only reason for their divorce. She didn't really want to get into specifics, but she wasn't afraid to tease that there were additional issues between her and Turner.

Earlier this month, Turner told People magazine that he was diagnosed with bone marrow cancer in March, which greatly impacted his decision to get a divorce from Nist.

"Unfortunately, there's no cure for it," Turner told the outlet. "So that weighs heavily in every decision I make. It was like 10 tons of concrete were just dropped on me. And I was a bit in denial for a while, I didn't want to admit to it."

However, Nist told People that Turner's cancer diagnosis was not the reason she decided getting a divorce was a good idea.

"It was when I visited Gerry in Indiana [some time in March]," Nist recalled. "That's devastating news, really. I was extremely upset."

Speaking of the diagnosis, Nist said, "He told me, though, that it was the type of cancer that he would most likely outlive."

White House press secretary Karine Jean-Pierre’s last year on the job was marked by what many saw as more embarrassing clarifications behind the podium.

In 2024, Jean-Pierre dealt with several major political events surrounding President Biden, such as ongoing concerns over his mental acuity, his decision to drop out of the 2024 presidential race, and the pardon of his son Hunter after repeatedly insisting he wouldn’t.

White House reporters challenged Jean-Pierre on not just Biden’s responses to these issues but her own as well, accusing her of going back on her previous statements. This led to more numerous heated confrontations with the press.

Here are some of the more memorable interactions of 2024:

KARINE JEAN-PIERRE'S MOST MEMORABLE CLASHES WITH REPORTERS THROUGHOUT 2023

In January, Fox News’ Peter Doocy asked Jean-Pierre about polling that showed Americans having less trust in Biden’s mental acuity ahead of the presidential election. He specifically cited an ABC poll showing Biden’s rating for health down by five points since the previous May.

"You know, I have to say that's a little confusing for me, because if you look at what this president has done the last three years, historical pieces of legislation, right? When it comes to bipartisan infrastructure deal, many presidents before, like your favorite president, had said that—," she responded. 

"Who’s my favorite president?" Doocy interjected.

Jean-Pierre remarked, "Why don’t you … why don’t we let the American people guess?"

The two went back and forth for a few seconds as he pressed her further to explain her remark.

"I don’t understand what you’re getting at," Doocy said.

"Let me finish. Let me finish," Jean-Pierre insisted.

She went on to boast about the state of the economy, calling Biden a "pretty effective president" considering the legislation passed under him.

In March, Fox Business’ Edward Lawrence asked Jean-Pierre about the president being seen with notecards at multiple recent events.

Jean-Pierre shot back, "You're upset because the president has notecards? You're asking me a question about the president having notecards?"

Lawrence replied, "I’m asking why does he rely so heavily­–"

She cut him off, stating, "The president who has had probably one of the most successful first three years of an administration than any modern-day president? He's done more in the first three years than most presidents who have two terms. You're asking me about notecards? I don't think–"

When Lawrence followed up, Jean-Pierre deflected again, saying, "I think what's important here and what the American people care about is how this president is delivering for them. And that's what he's doing and that's what's the most important thing here."

In June, about one month before Biden stepped down from the race, several videos went viral showing the president wandering around aimlessly and looking frail, reigniting concerns over his age.

In response to these questions, Jean-Pierre referred to them as "a rash of videos that have been edited to make the president appear especially frail or mentally confused," and labeled them "cheap fakes," a phrase she attributed to the Washington Post, "pushing misinformation, disinformation."

"It tells you everything that we need to know about how desperate Republicans are here," Jean-Pierre said. "And instead of talking about the president’s performance in office, and what I mean by that is his legislative wins, what he’s been able to do for the American people across the country, we’re seeing these deepfakes, these manipulated videos. And it is, again, done in bad faith."

Despite her claim, one of the viral videos included a fundraiser with actor George Clooney, an event that eventually led to the actor calling for Biden to leave the presidential race.

JEAN-PIERRE BRISTLES WHEN PRESSED ON PAST 'DEMOCRACY' WARNINGS: 'DO NOT APPRECIATE HAVING MY WORDS TWISTED'

Weeks before Biden left the race in July, the New York Post released a series of reports revealing Dr. Kevin Cannard, a neurologist from Walter Reed Military Medical Center who specializes in Parkinson's disease, visited the White House and met with Biden’s doctor, Dr. Kevin O’Connor, several times over the past year.

Although Dr. Cannard’s name was listed on public visitor logs, Jean-Pierre refused to say any names, igniting a feud with CBS reporter Ed O'Keefe.

"It's a very basic, direct question," O'Keefe shouted, grabbing her attention. "That's what you should be able to answer by this point."

"No, no, no, no, no," Jean-Pierre immediately pushed back. "Ed, please. A little respect here. Please."

O’Keefe received help from NBC correspondent Kelly O'Donnell, who reiterated that the names were part of the public record.

"There's no reason to go back and forth with me in this aggressive way," Jean-Pierre scolded the reporters. 

"Well, we are miffed around here about what has been shared with the press corps about him," an exasperated O'Keefe said. 

Just days after the second assassination attempt against eventual President-elect Donald Trump in September, Jean-Pierre rebuffed questions about whether Biden planned to stop referring to Trump as a "threat" to democracy.

"How many more assassination attempts on Donald Trump until the president and vice president and you pick a different word to describe Trump, other than ‘threat’?" Fox News' Peter Doocy asked.

She answered, "If anything from this administration, I completely disagree with the premise of your question. The question that you're asking also is incredibly dangerous in the way that you’re asking it because the American people are watching. And to say that, to say that from the administration who has consistently condemned political violence, from an administration where the president called the former president and was thankful, grateful that he was okay, from an administration that has called out Jan. 6, called out the attack on Paul Pelosi, called out and said we need to lower the temperature after the Butler incident."

"And now for you to make that kind of comment in your question because your question involved a comment and a statement, and that is also incredibly dangerous," Jean-Pierre said.

She also justified calling Trump a threat to democracy by invoking Jan. 6.

"I mean, if that's not a threat to our democracy, when it was one of the darkest days of our democracy – January 6th, one of the darkest days – then what is?" Jean-Pierre asked.

With just weeks to go in his presidency, Biden pardoned his son after previously emphatically insisting that he wouldn’t. 

Jean-Pierre had repeatedly said at the podium that a pardon was not on the table, even as a conviction was possible. A few days after Hunter Biden’s pardon, she was confronted about her comments.

"You were asked about the president pardoning his son, and you said, ‘It's a no. It will be a no. It's a no,'" AP White House correspondent Zeke Miller said, recounting Jean-Pierre's statements.

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"When you look at the statement, it's pretty comprehensive," Jean-Pierre said, referring to Biden's full statement justifying the pardon, adding that the "circumstances have changed."

Miller pushed back on this answer, reminding her of her promises when taking the job as press secretary.

"In your first briefing here as press secretary, you committed to speaking ‘in a transparent way, in a truthful way, and in an honest way,'" Miller told Jean-Pierre.

At the beginning of 2024, the American Cancer Society predicted that 2,001,140 new cancer cases and 611,720 cancer deaths would occur in the United States.

Now, as the year draws to a close, experts are looking back and reflecting on the discoveries and advances that have been made in the field of cancer treatment and prevention.

Fox News Digital spoke with four oncologists from the Sarah Cannon Research Institute in Nashville, Tennessee, about the most notable accomplishments of 2024 and what they see on the horizon for 2025. 

5 CANCER TYPES WHERE SCREENINGS SAVE THE MOST LIVES

See the answers and questions below. 

A: In the field of lymphomas, we see growing momentum for therapies that use the patient's own immune system to fight their cancer, such as CAR T-cell therapy and bispecific antibodies. 

These are treatments that are now being studied and are making an impact earlier in the disease course, including one now being studied as the very first treatment a patient might receive for their lymphoma. 

PANCREATIC CANCER PATIENT SURVIVAL DOUBLED WITH HIGH DOSE OF COMMON VITAMIN, STUDY FINDS

These treatments are helping us to be less dependent on chemotherapies (which may be effective but have broad side effects) for the treatment of lymphomas.  

A: Every year we are improving the curative treatment options we have for specific types of lymphomas, such as diffuse large B-cell lymphoma (DLBCL), which is the most common lymphoma we see. 

We are also gradually becoming better able to offer these treatments closer to – or in – patients’ homes and communities, so they can receive the best care as close to home as possible. 

I believe that in 2025, we will continue to see more advancement in immunotherapies, development of more targeted therapies (including oral medicines), and hopefully soon the approval of next generations of immunotherapies that may work for patients who have already received today's immunotherapies but need more treatment options.

A: It has changed and evolved dramatically. A decade ago, care for lymphomas was primarily chemotherapy-based. Now, we are shifting rapidly away from chemotherapies in some types of lymphomas in favor of immunotherapies and targeted oral therapies that lead to excellent long-term outcomes for patients, with fewer side effects than historical treatments.

A: We think of lymphomas as diseases of aging for most patients. Some patients may have select risk factors, such as being on specific immunosuppressants or having exposure to very specific industrial chemicals. 

Those risks may or may not be so modifiable for patients, and they represent the minority of patients who develop lymphoma. 

AI DETECTS WOMAN’S BREAST CANCER AFTER ROUTINE SCREENING MISSED IT: 'DEEPLY GRATEFUL'

While it is not entirely clear what modifiable risks patients may have, there is ongoing work to help better answer that question. However, we know that the better general health someone is in, the more likely they are to have any and all treatment options available to them. 

I would say that for most people, exercising regularly, eating well and sleeping regularly are important.

A: There is great hope and a lot of exciting science happening to help us drive toward more cures, more effective treatments and less toxic treatments for lymphomas. 

We have already made major strides in the last decade, and we continue to build on that momentum through clinical trials that provide early access to cutting-edge therapies. 

For patients, participating in clinical trials may help to close that time gap between the treatments that are broadly available today and the treatments we expect to be available years from now. 

They also provide a way for patients to contribute positively to the care patients in future generations may receive, which I have been told by many of my patients is something they really want to do and something that is important to them.

A: The two most exciting focuses of 2024 were 1) expansion of targeted therapies in the curative setting for hormonally driven breast cancer and 2) antibody drug conjugates. 

First, three different CDK4/6 inhibitors have been approved in the metastatic setting, and they improve survival and outcomes. 

In 2024, we saw the approval of a second one in the curative setting, enabling us to identify the highest-risk patients and offer them something additional to endocrine therapy to improve cure rates.

Second, we now have multiple antibody drug conjugates approved across all types of breast cancer. These therapies target a chemotherapy drug directly to the tumor via an antibody-honing mechanism and largely spare normal body cells.

A: I anticipate seeing more targeted agents in 2025 and the approval of antibody drug conjugates in curative early breast cancer — currently, most are only approved in metastatic cancer.

[I also anticipate] drugs that are better tolerated with decreased side effects for patients, and a continued emphasis on personalized medicine. 

A: In 2024, truly personalized medicine is possible, from mutation testing to direct targeted therapy to what a cancer needs to grow — as well as being able to provide many HR+ breast cancer patients with curative chemotherapy through personalized risk stratification assays.

A: Continued breast screening with mammograms yearly is really important to find cancers earlier when a cure is more likely.  

People can also reduce their risk through avoiding alcohol and cigarettes and making sure they get regular exercise and maintain a normal body weight.

A: In 2024, precision cancer treatment made big strides with many new drug approvals by the FDA, specifically for treatments guided by specific biomarkers, which means treatments can be more precisely tailored to the genetic makeup of a person's cancer. 

BREAST CANCER VACCINE UPDATE FROM CLEVELAND CLINIC: ‘A NEW ERA’

A key change was moving some therapies from faster, temporary approval processes to full approval, showing strong evidence that these targeted therapy drugs, such as tepotinib and amivantamab for certain types of lung cancer, are effective and safe. 

There were also new drug approvals for rare cancers, including tovorafenib, a BRAF precision medicine for a rare type of brain tumor in children, and afamitresgene autoleucel, a type of immunotherapy for a rare cancer called synovial sarcoma. This highlights important progress in treating these challenging conditions.

We have also seen the approval of precision therapies that work on different types of cancer — not just one specific cancer. This is what we call "tissue-agnostic therapies." 

One such drug is an antibody drug conjugate called trastuzumab deruxtecan, which acts like a smart missile targeting HER2-positive cancers. Another is repotrectinib, which works on any cancer that has the NTRK biomarker, regardless of where it is in the body.

A: By 2025, cancer research is likely to see advancements in precision oncology and the use of artificial intelligence. 

In precision oncology, we can expect more personalized treatment plans based on an individual's genetic makeup, leading to more effective and targeted therapies with fewer side effects. 

Additionally, AI will likely play a larger role in analyzing vast amounts of data to identify new drug targets, predict patient responses to treatments and enhance early detection methods. 

These advancements have the potential to improve cancer diagnosis, treatment and overall patient outcomes.

A: In the last 10 years, cancer treatment has changed dramatically. By using genetic information to create personalized treatments that match the specific details of each person's cancer, therapies are more effective and less harmful. 

New technologies such as analyzing cancer's genetic profile, blood tests that detect cancer, and treatments that boost the immune system have greatly improved how we diagnose, track and treat cancer, leading to better results for patients.

A: To lower the risk of cancer, people can avoid smoking, eat a healthy diet, exercise regularly, limit alcohol, protect their skin from the sun and maintain a healthy weight.

A: Get vaccines for viruses like HPV and hepatitis B, as they can lead to some cancers. Also, go for regular health checks to catch any signs of cancer early. 

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We are in a unique time when treatments can be tailored specifically to each person, and many of these are available through clinical trials. If you or a loved one is diagnosed with cancer, ask your doctor if there are any clinical trials that might be a good fit.

A: The first cellular therapy, Lifileucel, was approved in melanoma after decades of research in academia and industry. 

This is a significant step forward for both patients with melanoma, but also the field of oncology at large.

A: As we look to bring effective therapies from the metastatic setting into early stages of disease, we are anxiously awaiting updates in the next 18 to 24 months for a number of ongoing trials for combination therapy for patients with high-risk stage 2 or 3 melanoma.

A: Outcomes for melanoma have significantly changed over the past 10 years. 

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The five-year survival for patients with a diagnosis of stage 4 melanoma was less than 5% before 2010, and now clinical trials have shown that more than 50% of patients are still alive 10 years after being treated with FDA-approved immune checkpoint inhibitors.

A: Lifelong sun protective measures, such as wearing sunscreen, avoiding direct UV exposure during peak hours of 10 a.m. to 2 p.m., and avoiding tanning beds continue to be important starting at an early age.