NASA and its international partners have hosted research experiments and fostered collaboration aboard the International Space Station for over 25 years. More than 4,000 investigations have been conducted, resulting in over 4,400 research publications with 361 in 2024 alone. Space station research continues to advance technology on Earth and prepare for future space exploration missions.

Below is a selection of scientific results that were published over the past year. For more space station research achievements and additional information about the findings mentioned here, check out the 2024 Annual Highlights of Results:

• Full Report (PDF)
• Station Research Results website (with extra features)

Making stronger cement

NASA’s Microgravity Investigation of Cement Solidification (MICS) observes the hydration reaction and hardening process of cement paste on the space station. As part of this experiment, researchers used artificial intelligence to create 3D models from 2D microscope images of cement samples formed in microgravity. Characteristics such as pore distribution and crystal growth can impact the integrity of any concrete-like material, and these artificial intelligence models allow for predicting internal structures that can only be adequately captured in 3D. Results from the MICS investigation improve researchers’ understanding of cement hardening and could support innovations for civil engineering, construction, and manufacturing of industrial materials on exploration missions.

Creating Ideal Clusters

The JAXA (Japan Aerospace Exploration Agency) Colloidal Clusters investigation uses the attractive forces between oppositely charged particles to form pyramid-shaped clusters. These clusters are a key building block for the diamond lattice, an ideal structure in materials with advanced light-manipulation capabilities. Researchers immobilized clusters on the space station using a holding gel with increased durability. The clusters returned to Earth can scatter light in the visible to near-infrared range used in optical and laser communications systems. By characterizing these clusters, scientists can gain insights into particle aggregation in nature and learn how to effectively control light reflection for technologies that bend light, such as specialized sensors, high-speed computing components, and even novel cloaking devices.

Controlling Bubble Formation

NASA’s Optical Imaging of Bubble Dynamics on Nanostructured Surfaces studies how different types of surfaces affect bubbles generated by boiling water on the space station. Researchers found that boiling in microgravity generates larger bubbles and that bubbles grow about 30 times faster than on Earth. Results also show that surfaces with finer microstructures generate slower bubble formation due to changes in the rate of heat transfer. Fundamental insights into bubble growth could improve thermal cooling systems and sensors that use bubbles.

Evaluating Cellular Responses to Space

The ESA (European Space Agency) investigation Cytoskeleton attempts to uncover how microgravity impacts important regulatory processes that control cell multiplication, programmed cell death, and gene expression. Researchers cultured a model of human bone cells and identified 24 pathways that are affected by microgravity. Cultures from the space station showed a reduction of cellular expansion and increased activity in pathways associated with inflammation, cell stress, and iron-dependent cell death. These results help to shed light on cellular processes related to aging and the microgravity response, which could feed into the development of future countermeasures to help maintain astronaut health and performance.

Improving Spatial Awareness

The CSA (Canadian Space Agency) investigation Wayfinding investigates the impact of long-duration exposure to microgravity on the orientation skills in astronauts. Researchers identified reduced activity in spatial processing regions of the brain after spaceflight, particularly those involved in visual perception and orientation of spatial attention. In microgravity, astronauts cannot process balance cues normally provided by gravity, affecting their ability to perform complex spatial tasks. A better understanding of spatial processes in space allows researchers to find new strategies to improve the work environment and reduce the impact of microgravity on the spatial cognition of astronauts.

Monitoring low Earth orbit

The Roscomos-ESA-Italian Space Agency investigation Mini-EUSO (Multiwavelength Imaging New Instrument for the Extreme Universe Space Observatory) is a multipurpose telescope designed to examine light emissions entering Earth’s atmosphere. Researchers report that Mini-EUSO data has helped to develop a new machine learning algorithm to detect space debris and meteors that move across the field of view of the telescope. The algorithm showed increased precision for meteor detection and identified characteristics such as rotation rate. The algorithm could be implemented on ground-based telescopes or satellites to identify space debris, meteors, or asteroids and increase the safety of space activities.

For more space station research achievements and additional information about the findings mentioned here, check out the 2024 Annual Highlights of Results.

Destiny Doran

International Space Station Research Communications Team

Johnson Space Center

NASA will provide live launch and docking coverage of a Roscosmos cargo spacecraft delivering approximately three tons of food, fuel, and supplies for the crew aboard the International Space Station.

The unpiloted Roscosmos Progress 91 spacecraft is scheduled to launch at 4:24 p.m. EST, Thursday, Feb. 27 (2:24 a.m. Baikonur time, Friday, Feb. 28), on a Soyuz rocket from the Baikonur Cosmodrome in Kazakhstan.

Live launch coverage will begin at 4 p.m. on NASA+. Learn how to watch NASA content through a variety of platforms, including social media.

After a two-day in-orbit journey to the station, the spacecraft will dock autonomously to the aft port of the Zvezda service module at 6:03 p.m. Saturday, March 1. NASA’s rendezvous and docking coverage will begin at 5:15 p.m. on NASA+.

The Progress 91 spacecraft will remain docked to the space station for approximately six months before departing for re-entry into Earth’s atmosphere to dispose of trash loaded by the crew.

The International Space Station is a convergence of science, technology, and human innovation that enables research not possible on Earth. For more than 24 years, NASA has supported a continuous U.S. human presence aboard the orbiting laboratory, through which astronauts have learned to live and work in space for extended periods of time. The space station is a springboard for developing a low Earth economy and NASA’s next great leaps in exploration, including missions to the Moon under Artemis and, ultimately, human exploration of Mars.

Get breaking news, images and features from the space station on Instagram, Facebook, and X.

Learn more about the International Space Station, its research, and its crew, at:

https://www.nasa.gov/station

-end-

Claire O’Shea
Headquarters, Washington
202-358-1100
claire.a.o’shea@nasa.gov

Sandra Jones
Johnson Space Center, Houston
281-483-5111
sandra.p.jones@nasa.gov

Improving space-based pharmaceutical research

Researchers found differences in the stability and degradation of the anti-Covid drug Remdesivir in space and on Earth on its first research flight, but not on a second. This highlights the need for more standardized procedures for pharmaceutical research in space.

Long-term stability of drugs is critical for future space missions. Because multiple characteristics of spaceflight could influence chemical stability, the scientists repeated their experiment under circumstances as nearly identical as possible. This research used Kirara, a temperature-controlled incubator developed by JAXA (Japan Aerospace Exploration Agency) for crystallizing proteins in microgravity. Results also confirmed that a solubility enhancer used in the drug is radiation resistant and its quality was not affected by microgravity and launch conditions.

Evaluating postflight task performance

Immediately after returning from the International Space Station and for up to one week, astronauts perform functional tasks in ways similar to patients on Earth who have a loss of inner ear function. This finding suggests that comparing data from these patients and astronauts could provide insight into the role of the balance and sensory systems in task performance during critical parts of a mission such as landing on the Moon or Mars.   

Spaceflight causes changes to the balance (vestibular) and sensory systems that can lead to symptoms such as disorientation and impaired locomotion. Standard Measures collects a set of data, including tests of sensorimotor function, related to human spaceflight risks from astronauts before, during, and after missions to help characterize how people adapt to living and working in space.

In an effort to learn more about astronaut health and the effects of space on the human body, NASA is conducting a new experiment aboard the International Space Station to speed up the detection of antibiotic-resistant bacteria, thus improving the health safety not only of astronauts but patients back on Earth.

Infections caused by antibiotic-resistant bacteria can be difficult or impossible to treat, making antibiotic resistance a leading cause of death worldwide and a global health concern.

Future astronauts visiting the Moon or Mars will need to rely on a pre-determined supply of antibiotics in case of illness. Ensuring those antibiotics remain effective is an important safety measure for future missions.

The Genomic Enumeration of Antibiotic Resistance in Space (GEARS) experiment, which is managed by NASA’s Ames Research Center in California’s Silicon Valley, involves astronauts swabbing interior surfaces across the space station and testing those samples for evidence of antibiotic-resistant bacteria, and in particular Enterococcus faecalis, a type of bacteria commonly found in the human body. The experiment is the first step in a series of work that seeks to better understand how organisms grow in a space environment, and how those similarities and differences might help improve research back on Earth.

“Enterococcus is a type of organism that’s been with us since our ancestors crawled out of the ocean, and is a core member of the human gut,” said Christopher Carr, assistant professor at the Georgia Institute of Technology and co-principal investigator of GEARS. “It’s able to survive inside and outside of its host, which has allowed it to become the second highest leading cause of hospital-acquired infections. We want to understand how this type of organism is adapting to the space environment.”

The GEARS experiment seeks to improve the detection and identification of these bacteria, building on existing efforts to understand what organisms grow on the station’s surfaces.

“We’ve been monitoring the surfaces of the space station since 2000, but this experiment will give us insight beyond the identities of present organisms, which is currently all that is used for risk assessment,” said Sarah Wallace, a microbiologist at NASA’s Johnson Space Center in Houston and co-principal investigator of GEARS. “With the station orbiting close to Earth, it’s a low-risk space to evaluate and learn more about the frequency of this bacteria and how it responds to the space environment so we can apply this understanding to missions to the Moon and Mars, where resupplies are more complex.”

Over the next year, astronauts will swab parts of the station and analyze samples by adding an antibiotic to the medium in which the samples will grow. The results will reveal where this and other resistant bacteria are growing and whether they can persist or spread across the station.

The experiment was originally launched to the ISS on the 30^th SpaceX commercial resupply services (CRS) mission in March 2024, and the first round of GEARS testing turned up surprising results: very few resistant bacteria colonies, none of which were E. faecalis. This bodes well for the threat of antibiotic resistance in space.

“There was some cleaning done before swabbing the station, which may have removed some bacteria,” said Carr. To better understand how and where risky bacteria may live, the astronauts paused some cleaning before the second round of swabbing.

“We want the astronauts to have a clean environment, but we also want to test those high-touch areas, so they intentionally and briefly avoided cleaning some areas so we can understand how bacteria may grow or spread on the station.”

This experiment is the first study to perform metagenomic sequencing in space, a method that analyzes all the genetic material in a sample to identify and characterize all organisms that are present, an important research and medical diagnostic capability for future deep space missions.

The GEARS team hopes to create a rapid workflow to analyze bacteria samples, reducing the time between swabbing and test results from days to hours. That workflow could be applied in hospitals and make a huge impact when treating hospital-acquired infections from antibiotic-resistant microbes.

The result could save lives – more than 35,000 people die each year as a result of antibiotic-resistant infections. The issue is personal to Wallace, who lost a family member to a hospital-acquired infection.

“It’s not that uncommon: so many people have experienced this kind of loss,” said Wallace. “A method to give an answer in a matter of hours is huge and profound. It’s my job to keep the crew healthy, but we’re also passionate about bringing that work back down to Earth. I hope we can shine a light on rapidly analyzing bacteria: if we can do this in space, we can do it on Earth, too.”

Genomic Enumeration of Antibiotic Resistance in Space (GEARS) was funded by the Biological and Physical Sciences Space Biology Program, with pioneering funding and support from the Mars Campaign office.

Editor’s note: NASA is rescheduling its upcoming Expedition 73 mission overview briefing and crew news conference originally planned on Monday, Feb. 24. The mission overview briefing now is anticipated to follow NASA’s Crew-10 flight readiness review on Friday, March 7, and the crew news conference will follow the arrival of Crew-10 to the agency’s Kennedy Space Center in Florida. NASA astronaut Jonny Kim will be available on Tuesday, March 18, for limited virtual interviews prior to launch. NASA will share more information on the updated dates and times in the coming days.

Editor’s note: This advisory was updated on Feb. 20, 2025, to reflect an update in participants for the overview news conference.

NASA and its partners will discuss the upcoming Expedition 73 mission aboard the International Space Station during a pair of news conferences on Monday, Feb. 24, from the agency’s Johnson Space Center in Houston.

Mission leadership will participate in an overview news conference at 2 p.m. EST live on NASA+, covering preparations for NASA’s SpaceX Crew-10 launch in March and the agency’s crew member rotation launch on Soyuz in April. Learn how to watch NASA content through a variety of platforms, including social media.

NASA also will host a crew news conference at 4 p.m. and provide coverage on NASA+, followed by individual crew member interviews beginning at 5 p.m. This is the final media opportunity with Crew-10 before the crew members travel to NASA’s Kennedy Space Center in Florida for launch.

The Crew-10 mission, targeted to launch Wednesday, March 12, will carry NASA astronauts Anne McClain and Nichole Ayers, JAXA (Japan Aerospace Exploration Agency) astronaut Takuya Onishi, and Roscosmos cosmonaut Kirill Peskov to the orbiting laboratory.

NASA astronaut Jonny Kim, scheduled to launch to the space station on the Soyuz MS-27 spacecraft no earlier than April 8, also will participate in the crew briefing and interviews. Kim will be available again on Tuesday, March 18, for limited virtual interviews prior to launch. NASA will provide additional details on that opportunity when available.

For the Crew-10 mission, a SpaceX Falcon 9 rocket and Dragon spacecraft will launch from Launch Complex 39A at NASA Kennedy. The three-person crew of Soyuz MS-27, including Kim and Roscosmos cosmonauts Sergey Ryzhikov and Alexey Zubritsky, will launch from the Baikonur Cosmodrome in Kazakhstan.

United States-based media seeking to attend in person must contact the NASA Johnson newsroom no later than 5 p.m. on Friday, Feb. 21, at 281-483-5111 or at jsccommu@mail.nasa.gov. U.S. and international media interested in participating by phone must contact NASA Johnson by 9:45 a.m. the day of the event.

U.S. and international media seeking remote interviews with the crew must submit requests to the NASA Johnson newsroom by 5 p.m. on Feb. 21. A copy of NASA’s media accreditation policy is available online.

Briefing participants include (all times Eastern and subject to change based on real-time operations):

2 p.m.: Expedition 73 Overview News Conference

• Ken Bowersox, associate administrator, Space Operations Mission Directorate at NASA Headquarters in Washington

• Steve Stich, manager, NASA’s Commercial Crew Program, NASA Kennedy
• Dana Weigel, manager, NASA’s International Space Station Program, NASA Johnson
• William Gerstenmaier, vice president, Build & Flight Reliability, SpaceX
• Mayumi Matsuura, vice president and director general, Human Spaceflight Technology Directorate, JAXA

4 p.m.: Expedition 73 Crew News Conference

• Jonny Kim, Soyuz MS-27 flight engineer, NASA
• Anne McClain, Crew-10 spacecraft commander, NASA
• Nichole Ayers, Crew-10 pilot, NASA
• Takuya Onishi, Crew-10 mission specialist, JAXA
• Kirill Peskov, Crew-10 mission specialist, Roscosmos

5 p.m.: Crew Individual Interview Opportunities

• Crew-10 members and Kim available for a limited number of interviews

Kim is making his first spaceflight after selection as part of the 2017 NASA astronaut class. A native of Los Angeles, Kim is a U.S. Navy lieutenant commander and dual designated naval aviator and flight surgeon. Kim also served as an enlisted Navy SEAL. He holds a bachelor’s degree in Mathematics from the University of San Diego and a medical degree from Harvard Medical School in Boston. He completed his internship with the Harvard Affiliated Emergency Medicine Residency at Massachusetts General Hospital and Brigham and Women’s Hospital. After completing the initial astronaut candidate training, Kim supported mission and crew operations in various roles, including the Expedition 65 lead operations officer, T-38 operations liaison, and space station capcom chief engineer. Follow @jonnykimusa on X and @jonnykimusa on Instagram.

Selected by NASA as an astronaut in 2013, this will be McClain’s second spaceflight. A colonel in the U.S. Army, she earned her bachelor’s degree in Mechanical Engineering from the U.S. Military Academy at West Point, New York, and holds master’s degrees in Aerospace Engineering, International Security, and Strategic Studies. The Spokane, Washington, native was an instructor pilot in the OH-58D Kiowa Warrior helicopter and is a graduate of the U.S. Naval Test Pilot School in Patuxent River, Maryland. McClain has more than 2,300 flight hours in 24 rotary and fixed-wing aircraft, including more than 800 in combat, and was a member of the U.S. Women’s National Rugby Team. On her first spaceflight, McClain spent 204 days as a flight engineer during Expeditions 58 and 59, and completed two spacewalks, totaling 13 hours and 8 minutes. Since then, she has served in various roles, including branch chief and space station assistant to the chief of NASA’s Astronaut Office. Follow @astroannimal on X and @astro_annimal on Instagram.

The Crew-10 mission will be the first spaceflight for Ayers, who was selected as a NASA astronaut in 2021. Ayers is a major in the U.S. Air Force and the first member of NASA’s 2021 astronaut class named to a crew. The Colorado native graduated from the Air Force Academy in Colorado Springs with a bachelor’s degree in Mathematics and a minor in Russian, where she was a member of the academy’s varsity volleyball team. She later earned a master’s in Computational and Applied Mathematics from Rice University in Houston. Ayers served as an instructor pilot and mission commander in the T-38 ADAIR and F-22 Raptor, leading multinational and multiservice missions worldwide. She has more than 1,400 total flight hours, including more than 200 in combat. Follow @astro_ayers on X and @astro_ayers on Instagram.

With 113 days in space, this mission also will mark Onishi’s second trip to the space station. After being selected as an astronaut by JAXA in 2009, he flew as a flight engineer for Expeditions 48 and 49, becoming the first Japanese astronaut to robotically capture the Cygnus spacecraft. He also constructed a new experimental environment aboard Kibo, the station’s Japanese experiment module. After his first spaceflight, Onishi became certified as a JAXA flight director, leading the team responsible for operating Kibo from JAXA Mission Control in Tsukuba, Japan. He holds a bachelor’s degree in Aeronautics and Astronautics from the University of Tokyo, and was a pilot for All Nippon Airways, flying more than 3,700 flight hours in the Boeing 767. Follow astro_onishi on X.

The Crew-10 mission will also be Peskov’s first spaceflight. Before his selection as a cosmonaut in 2018, he earned a degree in Engineering from the Ulyanovsk Civil Aviation School and was a co-pilot on the Boeing 757 and 767 aircraft for airlines Nordwind and Ikar. Assigned as a test cosmonaut in 2020, he has additional experience in skydiving, zero-gravity training, scuba diving, and wilderness survival.

Learn more about how NASA innovates for the benefit of humanity through NASA’s Commercial Crew Program at:

https://www.nasa.gov/commercialcrew

-end-

Joshua Finch / Jimi Russell
Headquarters, Washington
202-358-1100
joshua.a.finch@nasa.gov / james.j.russell@nasa.gov

Kenna Pell / Sandra Jones
Johnson Space Center, Houston
281-483-5111
kenna.m.pell@nasa.gov / sandra.p.jones@nasa.gov

The 2024 Annual Highlights of Results from the International Space Station is now available. This new edition contains updated bibliometric analyses, a list of all the publications documented in fiscal year 2024, and synopses of the most recent and recognized scientific findings from investigations conducted on the space station. These investigations are sponsored by NASA and all international partners – CSA (Canadian Space Agency), ESA (European Space Agency), JAXA (Japan Aerospace Exploration Agency), and the State Space Corporation Roscosmos (Roscosmos) – for the advancement of science, technology, and education.

Between Oct. 1, 2023, and Sept. 30, 2024, more than 350 publications were reported. With approximately 40% of the research produced in collaboration between more than two countries and almost 80% of the high-impact studies published in the past seven years, station has continued to generate compelling and influential science above national and global standards since 2010.

The results achieved from station research provide insights that advance the commercialization of space and benefit humankind.

Some of the findings presented in this edition include:

• Improved machine learning algorithms to detect space debris (Italian Space Agency, Roscosmos, ESA)
• Visuospatial processing before and after spaceflight (CSA)
• Metabolic changes during fasting intervals in astronauts (ESA)
• Vapor bubble production for the improvement of thermal systems (NASA)
• Immobilization of particles for the development of optical materials (JAXA)
• Maintained function of cardiac 3D stem cells after weeks of exposure to space (NASA)

The content in the Annual Highlights of Results from the International Space Station has been reviewed and approved by the International Space Station Program Science Forum, a team of scientists and administrators representing NASA and international partners that are dedicated to planning, improving, and communicating the research operated on the space station.

[See the list of Station Research Results publications here and find the current edition of the Annual Highlights of Results here.]  

Modeling properties of thunderstorm discharges

Researchers report detailed physical properties of different types of corona discharges, including single- and multi-pulse blue discharges linked to powerful but short-lived electrical bursts near the tops of clouds. These details provide a reference for further investigation into the physical mechanisms behind these discharges and their role in the initiation of lightning, an important problem in lightning physics.

An ESA (European Space Agency) instrument used to study thunderstorms, Atmosphere-Space Interactions Monitor (ASIM) provides insights into their role in Earth’s atmosphere and climate, including mechanisms behind the creation of lightning. Understanding how thunderstorms and lightning disturb the upper atmosphere could improve atmospheric models along with climate and weather predictions. These high-altitude discharges also affect aircraft and spacecraft safety.

Evaluating effects of climate change on oceans

Researchers conclude that the space station’s ECOSTRESS instrument yields highly accurate sea surface temperature data. Given the instrument’s global coverage and high spatial resolution, these data have potential use in studies of biological and physical oceanography to evaluate regional and local effects of climate change.

ECOSTRESS resolves oceanographic features not detectable in imagery from NOAA’s Visible Infrared Imaging Radiometer Suite satellite, and has open-ocean coverage, unlike Landsat. Satellites are a fundamental tool to measure sea surface temperatures, which are rising across all oceans due to atmospheric warming induced by climate change.

Describing a gamma ray burst

Researchers report detailed observations and analysis of emissions from an exceptionally bright gamma ray burst (GRB), 210619B, detected by the station’s ASIM and other satellite and ground-based instruments. These observations could be useful in determining various properties of GRBs and how they change during different phases.

Believed to be generated by the collapse of massive stars, GRBs are the brightest, most explosive transient electromagnetic events in the universe. ASIM can observe thunderstorm discharges difficult to observe from the ground. It has a mode where a detected event triggers observation and onboard storage of data.

Science in Space: February 2025

February was first proclaimed as American Heart Month in 1964. Since then, its 28 (or 29) days have served as an opportunity to encourage people to focus on their cardiovascular health.

The International Space Station serves as a platform for a variety of ongoing research on human health, including how different body systems adapt to weightlessness. This research includes assessing cardiovascular health in astronauts during and after spaceflight and other studies using models of the cardiovascular system, such as tissue cultures. The goal of this work is to help promote heart health for humans in space and everyone on Earth. For this Heart Month, here is a look at some of this spaceflight research

Building a better heart model

Microgravity exposure is known to cause changes in cardiovascular function. Engineered Heart Tissues assessed these changes using 3D cultured cardiac tissues that model the behavior of actual heart tissues better than traditional cell cultures. When exposed to weightlessness, these “heart-on-a-chip” cells behaved in a manner similar to aging on Earth. This finding suggests that these engineered tissues can be used to investigate the effects of space radiation and long-duration spaceflight on cardiac function. Engineered tissues also could support development of measures to help protect crew members during a mission to Mars. Advanced 3D culture methodology may inform development of strategies to prevent and treat cardiac diseases on Earth as well.

Private astronaut heart health

For decades, human research in space has focused on professional and government-agency astronauts, but commercial spaceflight opportunities now allow more people to participate in microgravity research. Cardioprotection Ax-1 analyzed cardiovascular and general health in private astronauts on the 17-day Axiom-1 mission.

The study found that 14 health biomarkers related to cardiac, liver, and kidney health remained within normal ranges during the mission, suggesting that spaceflight did not significantly affect the health of the astronaut subjects. This study paves the way for monitoring and studying the effects of spaceflight on private astronauts and developing health management plans for commercial space providers.

Better measurements for better health

Vascular Echo, an investigation from CSA (Canadian Space Agency), examined blood vessels and the heart using a variety of tools, including ultrasound. A published study suggests that 3D imaging technology might better measure cardiac and vascular anatomy than the 2D system routinely used on the space station. The research team also developed a probe for the ultrasound device that better directs the beam, making it possible for someone who is not an expert in sonography to take precise measurements. This technology could help astronauts monitor heart health and treat cardiovascular issues on a long-duration mission to the Moon or Mars. The technology also could help patients on Earth who live in remote locations, where an ultrasound operator may not always be available.

Long-term heart health in space

As part of exploring ways to keep astronauts healthy on missions to the Moon and Mars, NASA is conducting a suite of space station studies called CIPHER that looks at the effects of spaceflight lasting up to a year. One CIPHER study, Vascular Calcium, examines whether calcium lost from bone during spaceflight might deposit in the arteries, increasing vessel stiffness and contributing to increased risk of future cardiovascular disease. Astronaut volunteers provide blood and urine samples and undergo ultrasound and high-resolution scans of their bones and arteries for this investigation. Another CIPHER study, Coronary Responses, uses advanced imaging tests to measure heart and artery response to spaceflight.

These studies will help scientists determine whether spaceflight accelerates narrowing and stiffening of the arteries, known as atherosclerosis, or increases the risk of atrial fibrillation, a rapid and irregular heartbeat seen in middle-aged adults. This work also could help identify potential biomarkers and early warning indicators of cardiovascular disease.

Melissa Gaskill

International Space Station Research Communications Team

Johnson Space Center

In an effort to learn more about astronaut health and the effects of space on the human body, NASA is conducting a new experiment aboard the International Space Station to speed up the detection of antibiotic-resistant bacteria, thus improving the health safety not only of astronauts but patients back on Earth.

Infections caused by antibiotic-resistant bacteria can be difficult or impossible to treat, making antibiotic resistance a leading cause of death worldwide and a global health concern.

Future astronauts visiting the Moon or Mars will need to rely on a pre-determined supply of antibiotics in case of illness. Ensuring those antibiotics remain effective is an important safety measure for future missions.

The Genomic Enumeration of Antibiotic Resistance in Space (GEARS) experiment, which is managed by NASA’s Ames Research Center in California’s Silicon Valley, involves astronauts swabbing interior surfaces across the space station and testing those samples for evidence of antibiotic-resistant bacteria, and in particular Enterococcus faecalis, a type of bacteria commonly found in the human body. The experiment is the first step in a series of work that seeks to better understand how organisms grow in a space environment, and how those similarities and differences might help improve research back on Earth.

“Enterococcus is a type of organism that’s been with us since our ancestors crawled out of the ocean, and is a core member of the human gut,” said Christopher Carr, assistant professor at the Georgia Institute of Technology and co-principal investigator of GEARS. “It’s able to survive inside and outside of its host, which has allowed it to become the second highest leading cause of hospital-acquired infections. We want to understand how this type of organism is adapting to the space environment.”

The GEARS experiment seeks to improve the detection and identification of these bacteria, building on existing efforts to understand what organisms grow on the station’s surfaces.

“We’ve been monitoring the surfaces of the space station since 2000, but this experiment will give us insight beyond the identities of present organisms, which is currently all that is used for risk assessment,” said Sarah Wallace, a microbiologist at NASA’s Johnson Space Center in Houston and co-principal investigator of GEARS. “With the station orbiting close to Earth, it’s a low-risk space to evaluate and learn more about the frequency of this bacteria and how it responds to the space environment so we can apply this understanding to missions to the Moon and Mars, where resupplies are more complex.”

Over the next year, astronauts will swab parts of the station and analyze samples by adding an antibiotic to the medium in which the samples will grow. The results will reveal where this and other resistant bacteria are growing and whether they can persist or spread across the station.

The experiment was originally launched to the ISS on the 30^th SpaceX commercial resupply services (CRS) mission in March 2024, and the first round of GEARS testing turned up surprising results: very few resistant bacteria colonies, none of which were E. faecalis. This bodes well for the threat of antibiotic resistance in space.

“There was some cleaning done before swabbing the station, which may have removed some bacteria,” said Carr. To better understand how and where risky bacteria may live, the astronauts paused some cleaning before the second round of swabbing.

“We want the astronauts to have a clean environment, but we also want to test those high-touch areas, so they intentionally and briefly avoided cleaning some areas so we can understand how bacteria may grow or spread on the station.”

This experiment is the first study to perform metagenomic sequencing in space, a method that analyzes all the genetic material in a sample to identify and characterize all organisms that are present, an important research and medical diagnostic capability for future deep space missions.

The GEARS team hopes to create a rapid workflow to analyze bacteria samples, reducing the time between swabbing and test results from days to hours. That workflow could be applied in hospitals and make a huge impact when treating hospital-acquired infections from antibiotic-resistant microbes.

The result could save lives – more than 35,000 people die each year as a result of antibiotic-resistant infections. The issue is personal to Wallace, who lost a family member to a hospital-acquired infection.

“It’s not that uncommon: so many people have experienced this kind of loss,” said Wallace. “A method to give an answer in a matter of hours is huge and profound. It’s my job to keep the crew healthy, but we’re also passionate about bringing that work back down to Earth. I hope we can shine a light on rapidly analyzing bacteria: if we can do this in space, we can do it on Earth, too.”

Genomic Enumeration of Antibiotic Resistance in Space (GEARS) was funded by the Biological and Physical Sciences Space Biology Program, with pioneering funding and support from the Mars Campaign office.

The latest edition of NASA’s Spinoff publication, which highlights the successful transfer of agency technology to the commercial sector, is now available online.

For nearly 25 years, NASA has supported crew working in low Earth orbit to learn about the space environment and perform research to advance deep space exploration. Astronauts aboard the International Space Station have learned a wealth of lessons and tried out a host of new technologies. This work leads to ongoing innovations benefiting people on Earth that are featured in NASA’s annual publication.  

“The work we do in space has resulted in navigational technologies, lifesaving medical advancements, and enhanced software systems that continue to benefit our lives on Earth,” said Clayton Turner, associate administrator, Space Technology Mission Directorate at NASA Headquarters in Washington. “Technologies developed today don’t just make life on our home planet easier – they pave the way to a sustained presence on the Moon and future missions to Mars.” 

The Spinoff 2025 publication features more than 40 commercial infusions of NASA technologies including: 

• A platform enabling commercial industry to perform science on the space station, including the growth of higher-quality human heart tissue, knee cartilage, and pharmaceutical crystals that can be grown on Earth to develop new medical treatments.  
• An electrostatic sprayer technology to water plants without the help of gravity and now used in sanitation, agriculture, and food safety.  
• “Antigravity” treadmills helping people with a variety of conditions run or walk for exercise, stemming from efforts to improve astronauts’ fitness in the weightlessness of space.  
• Nutritional supplements originally intended to keep astronauts fit and mitigate the health hazards of a long stay in space.  

As NASA continues advancing technology and research in low Earth orbit to establish a sustained presence at the Moon, upcoming lunar missions are already spinning off technologies on Earth. For example, Spinoff 2025 features a company that invented technology for 3D printing buildings on the Moon that is now using it to print large structures on Earth. Another group of researchers studying how to grow lunar buildings from fungus is now selling specially grown mushrooms and plans to build homes on Earth using the same concept.  

Spinoffs produce innovative technologies with commercial applications for the benefit of all. Other highlights of Spinoff 2025 include quality control on assembly lines inspired by artificial intelligence developed to help rovers navigate Mars, innovations in origami based on math for lasers and optical computing, and companies that will help lead the way to hydrogen-based energy building on NASA’s foundation of using liquid hydrogen for rocket fuel.  

“I’ve learned it’s almost impossible to predict where space technology will find an application in the commercial market,” said Dan Lockney, Technology Transfer program executive at NASA Headquarters in Washington. “One thing I can say for sure, though, is NASA’s technology will continue to spin off, because it’s our goal to advance our missions and bolster the American economy.”  

This publication also features 20 technologies available for licensing with the potential for commercialization. Check out the “Spinoffs of Tomorrow” section to learn more.

Spinoff is part of NASA’s Space Technology Mission Directorate and its Technology Transfer program. Tech Transfer is charged with finding broad, innovative applications for NASA-developed technology through partnerships and licensing agreements, ensuring agency investments benefit the nation and the world.  

To read the latest issue of Spinoff, visit: 

https://spinoff.nasa.gov

-end-

Jasmine Hopkins
Headquarters, Washington
321-432-4624
jasmine.s.hopkins@nasa.gov

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